Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-3-6
pubmed:abstractText
A consensus conference on the use of placebo in mood disorder studies consisted of expert presentations on bioethics, biostatistics, unipolar depression, and bipolar disorder. Work groups considered evidence and presented statements to the group. Although it was not possible to write a document for which there was complete agreement on all issues, the final document incorporated input from all authors. There was consensus that placebo has a definite role in mood disorder studies. Findings of equivalence between a new drug and standard treatment in active control studies is not evidence of efficacy unless the new drug is also significantly more effective than placebo. Add-on studies in which patients are randomized to standard therapy plus the investigational drug or standard therapy plus placebo are especially indicated for high-risk patients. Mood disorders in elderly and pediatric patients are understudied, and properly designed trials are urgently needed. Research is needed on the ethical conduct of studies to limit risks of medication-free intervals and facilitate poststudy treatment. Patients must fully understand the risks and lack of individualized treatment involved in research.
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0003-990X
pubmed:author
pubmed-author:BorensteinMichaelM, pubmed-author:BowdenCharles LCL, pubmed-author:CaplanArthurA, pubmed-author:CharneyDennis SDS, pubmed-author:Consensus Development Panel, pubmed-author:EmslieGraham JGJ, pubmed-author:EvansDwight LDL, pubmed-author:GellerBarbaraB, pubmed-author:GormanJack MJM, pubmed-author:GrabowskiLenore ELE, pubmed-author:HersonJayJ, pubmed-author:KalinNed HNH, pubmed-author:KeckPaul EPEJr, pubmed-author:KirschIrvingI, pubmed-author:KrishnanK Ranga RKR, pubmed-author:KupferDavid JDJ, pubmed-author:LadenSally KSK, pubmed-author:LaskaEugene MEM, pubmed-author:LewisLydiaL, pubmed-author:MakuchRobert WRW, pubmed-author:MillerFranklin GFG, pubmed-author:NemeroffCharles BCB, pubmed-author:PardesHerbertH, pubmed-author:PostRobertR, pubmed-author:ReynoldsMildred MMM, pubmed-author:RobertsLauraL, pubmed-author:RosenbaumJerrold FJF, pubmed-author:RosensteinDonald LDL, pubmed-author:RubinowDavid RDR, pubmed-author:RushA JohnAJ, pubmed-author:RyanNeal DND, pubmed-author:SachsGary SGS, pubmed-author:SchatzbergAlan FAF, pubmed-author:SolomonSusanS
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
262-70
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
National Depressive and Manic-Depressive Association consensus statement on the use of placebo in clinical trials of mood disorders.
pubmed:affiliation
Division of Intramural Research Programs, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. charneyd@nih.gov
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Consensus Development Conference, Consensus Development Conference, NIH