Source:http://linkedlifedata.com/resource/pubmed/id/11877435
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
21
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pubmed:dateCreated |
2002-5-20
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pubmed:abstractText |
Here we report the cellular arachidonate (AA)-releasing function of group IIF secretory phospholipase A(2) (sPLA(2)-IIF), a sPLA(2) enzyme uniquely containing a longer C-terminal extension. sPLA(2)-IIF increased spontaneous and stimulus-dependent release of AA, which was supplied to downstream cyclooxygenases and 5-lipoxygenase for eicosanoid production. sPLA(2)-IIF also enhanced interleukin 1-stimulated expression of cyclooxygenase-2 and microsomal prostaglandin E synthase. AA release by sPLA(2)-IIF was facilitated by oxidative modification of cellular membranes. Cellular actions of sPLA(2)-IIF occurred independently of the heparan sulfate proteoglycan glypican, which acts as a functional adaptor for other group II subfamily sPLA(2)s. Confocal microscopy revealed the location of sPLA(2)-IIF on the plasma membrane. The unique C-terminal extension was crucial for its plasma membrane localization and optimal cellular functions. sPLA(2)-IIF expression was increased in various tissues from lipopolysaccharide-treated mice and in ears of mice with experimental atopic dermatitis. In human rheumatoid arthritic joints, sPLA(2)-IIF was detected in synovial lining cells, capillary endothelial cells, and plasma cells. These results suggest that sPLA(2)-IIF is a potent regulator of AA metabolism and participates in the inflammatory process under certain conditions.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipases A,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipases A2
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0021-9258
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pubmed:author |
pubmed-author:GelbMichael HMH,
pubmed-author:InagakiNaokiN,
pubmed-author:IshiharaMotokoM,
pubmed-author:IshiiToshiharuT,
pubmed-author:IshikawaYukioY,
pubmed-author:KudoIchiroI,
pubmed-author:LambeauGeraldG,
pubmed-author:MurakamiMakotoM,
pubmed-author:NagaiHiroichiH,
pubmed-author:SawadaMasatsuguM,
pubmed-author:ShimbaraSatokoS,
pubmed-author:SingerAlan GAG,
pubmed-author:YoshiharaKumikoK
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
277
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19145-55
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11877435-Animals,
pubmed-meshheading:11877435-Arachidonic Acid,
pubmed-meshheading:11877435-Base Sequence,
pubmed-meshheading:11877435-Cell Line,
pubmed-meshheading:11877435-DNA Primers,
pubmed-meshheading:11877435-Dinoprostone,
pubmed-meshheading:11877435-Humans,
pubmed-meshheading:11877435-Inflammation,
pubmed-meshheading:11877435-Male,
pubmed-meshheading:11877435-Mice,
pubmed-meshheading:11877435-Mice, Inbred BALB C,
pubmed-meshheading:11877435-Mice, Inbred C57BL,
pubmed-meshheading:11877435-Phospholipases A,
pubmed-meshheading:11877435-Phospholipases A2,
pubmed-meshheading:11877435-Rats,
pubmed-meshheading:11877435-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Cellular arachidonate-releasing function and inflammation-associated expression of group IIF secretory phospholipase A2.
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pubmed:affiliation |
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. mako@pharm.showa-u.ac.jp
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pubmed:publicationType |
Journal Article
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