Linked Life Data

11876601

Source:http://linkedlifedata.com/resource/pubmed/id/11876601

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-3-5
pubmed:abstractText
Nitric oxide (NO) is a recognized mediator of inflammation in diseases affecting the lower respiratory tract, and has been implicated in the expression of viral upper respiratory tract infections. Here, exhaled nasal and oral NO concentrations and nitrite concentrations in nasal lavage fluids were measured, symptoms were scored and pulmonary function was evaluated before (Day 0) and after (Days 1-8) experimental exposure of 17 adult subjects to respiratory syncytial virus (RSV) type B. After exposure, RSV was recovered from 12 (70%) subjects by culture and/or specific antigen detection. Both subjects with and those without RSV recovery developed increased nasal and throat symptoms after RSV exposure, but none evidenced changes in the three measures of NO concentration. These results do not support the hypothesis of increased NO production during RSV infection and complement earlier studies that reported a lack of change in nasal NO concentration during experimental influenza and rhinovirus infections.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0001-6489
pubmed:author
pubmed:issnType
Print
pubmed:volume
122
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
61-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Nasal and oral nitric oxide levels during experimental respiratory syncytial virus infection of adults.
pubmed:affiliation
Department of Pediatrics, Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, Pennsylvania 15213, USA. gentild@chplink.chp.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.