Source:http://linkedlifedata.com/resource/pubmed/id/11873395
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2002-3-4
|
| pubmed:abstractText |
The natural course of Insulin Dependent Diabetes Mellitus is characterized by progressive destruction of insulin producing beta-cells of the pancreas resulting from an autoimmune process. The toxic effect of some beta-cells toxins like streptozotocin (used to produce animal models of IDDM) has been associated with the oxidative stress due to enhanced DNA repair and NAD depletion in damaged beta-cells. This activity of streptozotocin has been prevented with the use of nicotinamide.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1025-9589
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
26-30
|
| pubmed:dateRevised |
2004-8-12
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| pubmed:meshHeading |
pubmed-meshheading:11873395-Animals,
pubmed-meshheading:11873395-Anti-Bacterial Agents,
pubmed-meshheading:11873395-Diabetes Mellitus, Experimental,
pubmed-meshheading:11873395-Disease Models, Animal,
pubmed-meshheading:11873395-Islets of Langerhans,
pubmed-meshheading:11873395-Male,
pubmed-meshheading:11873395-Niacinamide,
pubmed-meshheading:11873395-Oxidative Stress,
pubmed-meshheading:11873395-Rats,
pubmed-meshheading:11873395-Streptozocin
|
| pubmed:articleTitle |
The optimum dose of nicotinamide for protection of pancreatic beta-cells against the cytotoxic effect of streptozotocin in albino rat.
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| pubmed:affiliation |
Department of Anatomy, Dow Medical College, Karachi.
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| pubmed:publicationType |
Journal Article
|