Linked Life Data

11872925

Source:http://linkedlifedata.com/resource/pubmed/id/11872925

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 2
pubmed:dateCreated
2002-3-1
pubmed:abstractText
Synchrotron fibre diffraction studies of collagenous breast tissue have revealed clear and consistent differences in the diffraction intensity patterns between samples taken from patients with breast carcinoma and those taken from controls. These changes, prelusive to carcinoma, are related to changes in and breakdown of the molecular structure of the collagen type IV support collagen adjacent to the type I, type III and type V collagen fibrils. In order to locate the positions and sequence of the different molecular arrangements, multiple samples were taken from a number of patients. The first of these was taken as near to the tumour site as was possible. Subsequent samples were taken at intervals along ducts leading away from the tumour. The results reveal that the collagen distal from the tumour is similar to that of the controls and this was taken as the standard molecular structure of breast tissue. It usually contained some fat. For normal samples taken closer to the tumour site, the wide diffraction ring associated with fat disappears leaving only the fibrillar pattern. Moving closer to the tumour a 'foetal-like tissue' was observed. The tissue immediately adjacent to the tumour was found to have the same molecular structure as that of foetal tissue.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0909-0495
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Synchrotron fibre diffraction identifies and locates foetal collagenous breast tissue associated with breast carcinoma.
pubmed:affiliation
Research School of Chemistry, Australian National University, Canberra, Australia. vjs@bigpond.com
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't