Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
2002-5-6
pubmed:abstractText
Cystic fibrosis (CF), a disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) chloride channel, is associated in the respiratory system with the accumulation of mucus and impaired lung function. The role of the CFTR channel in the regulation of the intracellular pathways that determine the overexpression of mucin genes is unknown. Using differential display, we have observed the differential expression of several mRNAs that may correspond to putative CFTR-dependent genes. One of these mRNAs was further characterized, and it corresponds to the tyrosine kinase c-Src. Additional results suggest that c-Src is a central element in the pathway connecting the CFTR channel with MUC1 overexpression and that the overexpression of mucins is a primary response to CFTR malfunction in cystic fibrosis, which occurs even in the absence of bacterial infection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
277
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17239-47
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11872746-Base Sequence, pubmed-meshheading:11872746-Blotting, Northern, pubmed-meshheading:11872746-Cell Line, pubmed-meshheading:11872746-Cloning, Molecular, pubmed-meshheading:11872746-Cystic Fibrosis, pubmed-meshheading:11872746-Cystic Fibrosis Transmembrane Conductance Regulator, pubmed-meshheading:11872746-Epithelial Cells, pubmed-meshheading:11872746-Gene Expression Profiling, pubmed-meshheading:11872746-Genes, Dominant, pubmed-meshheading:11872746-Humans, pubmed-meshheading:11872746-Immunoblotting, pubmed-meshheading:11872746-Immunohistochemistry, pubmed-meshheading:11872746-In Situ Hybridization, pubmed-meshheading:11872746-Lung, pubmed-meshheading:11872746-Microscopy, Confocal, pubmed-meshheading:11872746-Microscopy, Fluorescence, pubmed-meshheading:11872746-Molecular Sequence Data, pubmed-meshheading:11872746-Mucin-1, pubmed-meshheading:11872746-Mucins, pubmed-meshheading:11872746-Mutation, pubmed-meshheading:11872746-Oligonucleotides, Antisense, pubmed-meshheading:11872746-Plasmids, pubmed-meshheading:11872746-Proto-Oncogene Proteins pp60(c-src), pubmed-meshheading:11872746-RNA, Messenger, pubmed-meshheading:11872746-Transfection, pubmed-meshheading:11872746-Up-Regulation
pubmed:year
2002
pubmed:articleTitle
Tyrosine kinase c-Src constitutes a bridge between cystic fibrosis transmembrane regulator channel failure and MUC1 overexpression in cystic fibrosis.
pubmed:affiliation
Instituto de Investigaciones Bioquimicas Fundación Campomar (UBA, CONICET), 1405 Buenos Aires, Argentina.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't