Linked Life Data

11872246

Source:http://linkedlifedata.com/resource/pubmed/id/11872246

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2002-3-1
pubmed:abstractText
Actions of anandamide (10 microM) were examined on monosynaptic glutamatergic transmission from the periphery to substantia gelatinosa (SG) neurones in adult rat spinal cord slices using the whole-cell patch-clamp technique. In 64% of neurones examined, Adelta-fibre-evoked excitatory postsynaptic currents (EPSCs) were depressed (in amplitude; by 32 +/- 4%, n=21) by anandamide. On the contrary, an inhibitory action on C-fibre-evoked EPSCs was observed in only 31% of neurones tested; this magnitude (17 +/- 3%, n=4) was less than that of Adelta-fibre EPSCs (P<0.05). A cannabinoid-receptor agonist, WIN 55,212-2 (5 microM), exhibited similar actions on the EPSCs. In a neurone with minimal effects of anandamide on C-fibre EPSCs, capsaicin (1 microM) largely depressed the EPSCs (n=3); Adelta-fibre EPSCs were little affected by capsaicin. It is concluded that unlike capsaicin, anandamide inhibits more effectively Adelta-fibre than C-fibre-mediated excitatory transmission in the SG, possibly through the activation of the cannabinoid receptor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
321
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Anandamide inhibits excitatory transmission to rat substantia gelatinosa neurones in a manner different from that of capsaicin.
pubmed:affiliation
Department of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan.
pubmed:publicationType
Journal Article, Comparative Study