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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-2-28
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pubmed:abstractText |
NK cell function is regulated by a dual receptor system, which integrates signals from triggering receptors and MHC class I-specific inhibitory receptors. We show here that the src family kinase Fyn is required for efficient, NK cell-mediated lysis of target cells, which lack both self-MHC class I molecules and ligands for NKG2D, an activating NK cell receptor. In contrast, NK cell inhibition by the MHC class I-specific receptor Ly49A was independent of Fyn, suggesting that Fyn is specifically required for NK cell activation via non-MHC receptor(s). Compared to wild type, significantly fewer Fyn-deficient NK cells expressed the inhibitory Ly49A receptor. The presence of a transgenic Ly49A receptor together with its H-2(d) ligand strongly reduced the usage of endogenous Ly49 receptors in Fyn-deficient mice. These data suggest a model in which the repertoire of inhibitory Ly49 receptors is formed under the influenced of Fyn-dependent NK cell activation as well as the respective MHC class I environment. NK cells may acquire Ly49 receptors until they generate sufficient inhibitory signals to balance their activation levels. Such a process would ensure the induction of NK cell self-tolerance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AG 1879,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Fyn protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Klra1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Klrk1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Ly49I antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Specific Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fyn,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, NK Cell Lectin-Like,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Natural Killer Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/histocompatibility antigen H-2D(b)
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
773-82
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11870621-Animals,
pubmed-meshheading:11870621-Antigens, Ly,
pubmed-meshheading:11870621-CHO Cells,
pubmed-meshheading:11870621-Carrier Proteins,
pubmed-meshheading:11870621-Cricetinae,
pubmed-meshheading:11870621-Cricetulus,
pubmed-meshheading:11870621-Crosses, Genetic,
pubmed-meshheading:11870621-Cytotoxicity, Immunologic,
pubmed-meshheading:11870621-Enzyme Inhibitors,
pubmed-meshheading:11870621-H-2 Antigens,
pubmed-meshheading:11870621-Killer Cells, Lymphokine-Activated,
pubmed-meshheading:11870621-Killer Cells, Natural,
pubmed-meshheading:11870621-Lectins, C-Type,
pubmed-meshheading:11870621-Lymphocyte Activation,
pubmed-meshheading:11870621-Lymphocyte Specific Protein Tyrosine Kinase p56(lck),
pubmed-meshheading:11870621-Membrane Glycoproteins,
pubmed-meshheading:11870621-Membrane Proteins,
pubmed-meshheading:11870621-Mice,
pubmed-meshheading:11870621-Mice, Inbred C57BL,
pubmed-meshheading:11870621-Mice, Inbred Strains,
pubmed-meshheading:11870621-Mice, Transgenic,
pubmed-meshheading:11870621-NK Cell Lectin-Like Receptor Subfamily A,
pubmed-meshheading:11870621-NK Cell Lectin-Like Receptor Subfamily K,
pubmed-meshheading:11870621-Phosphorylation,
pubmed-meshheading:11870621-Protein Processing, Post-Translational,
pubmed-meshheading:11870621-Proto-Oncogene Proteins,
pubmed-meshheading:11870621-Proto-Oncogene Proteins c-fyn,
pubmed-meshheading:11870621-Pyrimidines,
pubmed-meshheading:11870621-Receptors, Immunologic,
pubmed-meshheading:11870621-Receptors, NK Cell Lectin-Like,
pubmed-meshheading:11870621-Receptors, Natural Killer Cell,
pubmed-meshheading:11870621-Recombinant Fusion Proteins,
pubmed-meshheading:11870621-Self Tolerance,
pubmed-meshheading:11870621-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors.
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pubmed:affiliation |
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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