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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-2-28
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pubmed:abstractText |
A 39-year-old man was found to have hyperproteinemia after being treated with zonisamide for 10 years. Laboratory examination revealed a serum M-protein which consisted of IgG (lambda) and an increased number of plasma cells in the bone marrow, resulting in a diagnosis of smoldering myeloma. Considering his age, zonisamide was suspected to play an etiologic role in the occurrence of smoldering myeloma. Zonisamide was changed to sodium valproate. Subsequently the M-protein did not increase over 13 months. When zonisamide is used, the monitoring of serum levels of M-protein and patterns of gammaglobulin is warranted.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0918-2918
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
138-41
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:11868602-Adult,
pubmed-meshheading:11868602-Agammaglobulinemia,
pubmed-meshheading:11868602-Anticonvulsants,
pubmed-meshheading:11868602-Epilepsy, Generalized,
pubmed-meshheading:11868602-Humans,
pubmed-meshheading:11868602-Immunoglobulin lambda-Chains,
pubmed-meshheading:11868602-Intracranial Arteriovenous Malformations,
pubmed-meshheading:11868602-Isoxazoles,
pubmed-meshheading:11868602-Male,
pubmed-meshheading:11868602-Multiple Myeloma,
pubmed-meshheading:11868602-Myeloma Proteins,
pubmed-meshheading:11868602-Subarachnoid Hemorrhage,
pubmed-meshheading:11868602-Valproic Acid
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pubmed:year |
2002
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pubmed:articleTitle |
Smoldering myeloma associated with zonisamide treatment.
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pubmed:affiliation |
Department of Laboratory Medicine, Tokai University School of Medicine, Isehara, Kanagawa.
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pubmed:publicationType |
Journal Article,
Case Reports
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