Linked Life Data

11867734

Source:http://linkedlifedata.com/resource/pubmed/id/11867734

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2002-3-7
pubmed:databankReference
pubmed:abstractText
The most impressive property of outer hair cells (OHCs) is their ability to change their length at high acoustic frequencies, thus providing the exquisite sensitivity and frequency-resolving capacity of the mammalian hearing organ. Prestin, a protein related to a sulfate/anion transport protein, recently has been identified and proposed as the OHC motor molecule. Homology searches of 1.5 kb of genomic DNA 5' of the coding region of the prestin gene allowed the identification of a thyroid hormone (TH) response element (TRE) in the first intron upstream of the prestin ATG codon. Prestin(TRE) bound TH receptors as a monomer or presumptive heterodimer and mediated a triiodothyronine-dependent transactivation of a heterologous promotor in response to triiodothyronine receptors alpha and beta. Retinoid X receptor-alpha had an additive effect. Expression of prestin mRNA and prestin protein was reduced strongly in the absence of TH. Although prestin protein typically was redistributed to the lateral membrane before the onset of hearing, an immature pattern of prestin protein distribution across the entire OHC membrane was noted in hypothyroid rats. The data suggest TH as a first transcriptional regulator of the motor protein prestin and as a direct or indirect modulator of subcellular prestin distribution.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-10022577, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-10191320, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-10457091, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-10529898, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-10655523, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-10760300, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-10805704, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-10821263, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-10845098, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-10875256, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-10956641, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-10978336, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-11125015, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-1528879, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-1601852, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-1648450, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-1987439, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-2155782, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-2747636, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-6508133, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-7410246, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-7690722, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-7701325, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-7890633, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-7961180, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-8034648, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-8366086, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-8385336, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-8673137, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-8861959, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-8968946, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-9441554, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-9716536, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-9727048, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-9861043, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-9886843, http://linkedlifedata.com/resource/pubmed/commentcorrection/11867734-9889331
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Anion Transport Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Luciferases, http://linkedlifedata.com/resource/pubmed/chemical/Pres protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thyroid Hormone, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins, http://linkedlifedata.com/resource/pubmed/chemical/SLC26A5 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators, http://linkedlifedata.com/resource/pubmed/chemical/Triiodothyronine
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2901-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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