| pubmed-article:11865396 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11865396 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:11865396 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:11865396 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:11865396 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:11865396 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:11865396 | lifeskim:mentions | umls-concept:C0012133 | lld:lifeskim |
| pubmed-article:11865396 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:11865396 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:11865396 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:11865396 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:11865396 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:11865396 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11865396 | pubmed:dateCreated | 2002-2-26 | lld:pubmed |
| pubmed-article:11865396 | pubmed:abstractText | The contribution of virologic and host factors to CD4 cell depletion associated with human immunodeficiency virus (HIV) type 1 was evaluated in children drawn from a larger efficacy trial of 2 doses of didanosine (ddI) monotherapy (Pediatric AIDS Clinical Trials Group 144). Thirty children, half with stable CD4 cell counts (non-progressors) and half with a marked decline in CD4 cells (progressors), were studied during 60-72 weeks of ddI therapy. The children were matched for age and CD4 cell counts at study entry. Three viral parameters, syncytium-inducing phenotype, higher virus load, and mutation in HIV-1 pol encoding the T69D/N mutation, were associated with disease progression. Disease progression was not associated with mutations in the reverse-transcriptase gene previously associated with resistance to ddI (L74V, K65R, or M184V). The selection of the T69D/N mutation in children with HIV-1 disease progression during ddI therapy suggests that this mutation confers a fitness advantage to the virus that may include resistance to ddI. | lld:pubmed |
| pubmed-article:11865396 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11865396 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11865396 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11865396 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11865396 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11865396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11865396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11865396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11865396 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11865396 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11865396 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:11865396 | pubmed:author | pubmed-author:FrenkelLisa... | lld:pubmed |
| pubmed-article:11865396 | pubmed:author | pubmed-author:NauglerWillsc... | lld:pubmed |
| pubmed-article:11865396 | pubmed:author | pubmed-author:YongFlorence... | lld:pubmed |
| pubmed-article:11865396 | pubmed:author | pubmed-author:CareyVincent... | lld:pubmed |
| pubmed-article:11865396 | pubmed:author | pubmed-author:DragavonJoan... | lld:pubmed |
| pubmed-article:11865396 | pubmed:author | pubmed-author:CoombsRobert... | lld:pubmed |
| pubmed-article:11865396 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11865396 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11865396 | pubmed:volume | 185 | lld:pubmed |
| pubmed-article:11865396 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11865396 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11865396 | pubmed:pagination | 448-55 | lld:pubmed |
| pubmed-article:11865396 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11865396 | pubmed:meshHeading | pubmed-meshheading:11865396... | lld:pubmed |
| pubmed-article:11865396 | pubmed:meshHeading | pubmed-meshheading:11865396... | lld:pubmed |
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| pubmed-article:11865396 | pubmed:meshHeading | pubmed-meshheading:11865396... | lld:pubmed |
| pubmed-article:11865396 | pubmed:meshHeading | pubmed-meshheading:11865396... | lld:pubmed |
| pubmed-article:11865396 | pubmed:meshHeading | pubmed-meshheading:11865396... | lld:pubmed |
| pubmed-article:11865396 | pubmed:meshHeading | pubmed-meshheading:11865396... | lld:pubmed |
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| pubmed-article:11865396 | pubmed:meshHeading | pubmed-meshheading:11865396... | lld:pubmed |
| pubmed-article:11865396 | pubmed:meshHeading | pubmed-meshheading:11865396... | lld:pubmed |
| pubmed-article:11865396 | pubmed:meshHeading | pubmed-meshheading:11865396... | lld:pubmed |
| pubmed-article:11865396 | pubmed:meshHeading | pubmed-meshheading:11865396... | lld:pubmed |
| pubmed-article:11865396 | pubmed:meshHeading | pubmed-meshheading:11865396... | lld:pubmed |
| pubmed-article:11865396 | pubmed:meshHeading | pubmed-meshheading:11865396... | lld:pubmed |
| pubmed-article:11865396 | pubmed:meshHeading | pubmed-meshheading:11865396... | lld:pubmed |
| pubmed-article:11865396 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11865396 | pubmed:articleTitle | T69D/N pol mutation, human immunodeficiency virus type 1 RNA levels, and syncytium-inducing phenotype are associated with CD4 cell depletion during didanosine therapy. | lld:pubmed |
| pubmed-article:11865396 | pubmed:affiliation | Department of Pediatrics, University of Washington, Seattle, WA, USA. | lld:pubmed |
| pubmed-article:11865396 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11865396 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11865396 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
