| pubmed-article:11865391 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11865391 | lifeskim:mentions | umls-concept:C0206679 | lld:lifeskim |
| pubmed-article:11865391 | lifeskim:mentions | umls-concept:C0013018 | lld:lifeskim |
| pubmed-article:11865391 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11865391 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11865391 | lifeskim:mentions | umls-concept:C0085110 | lld:lifeskim |
| pubmed-article:11865391 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:11865391 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:11865391 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:11865391 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:11865391 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11865391 | pubmed:dateCreated | 2002-2-26 | lld:pubmed |
| pubmed-article:11865391 | pubmed:abstractText | Severe combined immunodeficiency (SCID) mice with ill-developed Peyer's patches develop neither antibodies nor protection against lethal herpes simplex virus type 1 (HSV-1) infection by oral immunization. However, SCID mice carrying spleen cells from immunocompetent BALB/c mice had serum anti--HSV-1 antibody; anti--HSV-1 IgA antibody was detected in eye wash samples, and the mice were protected against lethal HSV-1 infection (88% survival rate). Western blotting showed that antibodies in SCID mice carrying spleen cells from BALB/c mice recognized 60-kDa HSV-1. The effector cells in transferred spleen cells were CD4(+), not CD8(+), T cells. Donor T cells were detected in the submucosal layer of the gut in SCID mice 1 day after transfer. Rapid movement of donor T cells to the gut may have a role in mucosal immunity to HSV-1. Thus, the normal environment for mucosal immunity develops in SCID mice without prior presence of CD4(+) T cells. | lld:pubmed |
| pubmed-article:11865391 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11865391 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11865391 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11865391 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11865391 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11865391 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11865391 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:11865391 | pubmed:author | pubmed-author:KoyamaA... | lld:pubmed |
| pubmed-article:11865391 | pubmed:author | pubmed-author:IrieHiroshiH | lld:pubmed |
| pubmed-article:11865391 | pubmed:author | pubmed-author:AitaKiyoshiK | lld:pubmed |
| pubmed-article:11865391 | pubmed:author | pubmed-author:FukudaAkioA | lld:pubmed |
| pubmed-article:11865391 | pubmed:author | pubmed-author:YoshidaTakesh... | lld:pubmed |
| pubmed-article:11865391 | pubmed:author | pubmed-author:ShigaJunjiJ | lld:pubmed |
| pubmed-article:11865391 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11865391 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11865391 | pubmed:volume | 185 | lld:pubmed |
| pubmed-article:11865391 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11865391 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11865391 | pubmed:pagination | 409-16 | lld:pubmed |
| pubmed-article:11865391 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11865391 | pubmed:meshHeading | pubmed-meshheading:11865391... | lld:pubmed |
| pubmed-article:11865391 | pubmed:meshHeading | pubmed-meshheading:11865391... | lld:pubmed |
| pubmed-article:11865391 | pubmed:meshHeading | pubmed-meshheading:11865391... | lld:pubmed |
| pubmed-article:11865391 | pubmed:meshHeading | pubmed-meshheading:11865391... | lld:pubmed |
| pubmed-article:11865391 | pubmed:meshHeading | pubmed-meshheading:11865391... | lld:pubmed |
| pubmed-article:11865391 | pubmed:meshHeading | pubmed-meshheading:11865391... | lld:pubmed |
| pubmed-article:11865391 | pubmed:meshHeading | pubmed-meshheading:11865391... | lld:pubmed |
| pubmed-article:11865391 | pubmed:meshHeading | pubmed-meshheading:11865391... | lld:pubmed |
| pubmed-article:11865391 | pubmed:meshHeading | pubmed-meshheading:11865391... | lld:pubmed |
| pubmed-article:11865391 | pubmed:meshHeading | pubmed-meshheading:11865391... | lld:pubmed |
| pubmed-article:11865391 | pubmed:meshHeading | pubmed-meshheading:11865391... | lld:pubmed |
| pubmed-article:11865391 | pubmed:meshHeading | pubmed-meshheading:11865391... | lld:pubmed |
| pubmed-article:11865391 | pubmed:meshHeading | pubmed-meshheading:11865391... | lld:pubmed |
| pubmed-article:11865391 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11865391 | pubmed:articleTitle | The role of donor CD4(+) T cells in the reconstitution of oral immunity by herpes simplex virus type 1 in severe combined immunodeficiency mice. | lld:pubmed |
| pubmed-article:11865391 | pubmed:affiliation | Department of Pathology, Teikyo University School of Medicine, Tokyo, 173-8605, Japan. h-irie@rb3.so-net.ne.jp | lld:pubmed |
| pubmed-article:11865391 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11865391 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11865391 | lld:pubmed |
