Linked Life Data

11865189

Source:http://linkedlifedata.com/resource/pubmed/id/11865189

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2002-2-26
pubmed:abstractText
The epidermal growth factor (EGF) receptor is activated not only by EGF-like ligands, but also by stimuli that do not directly act on the receptor, including agonists of G protein--coupled receptors and certain environmental stresses such as ionizing radiation. Carpenter discusses two reports that indicate EGF receptor activation by such heterologous stimuli may occur through the action of proteases that release cell surface EGF-like growth factor precursors. This mechanism of EGF receptor transactivation appears to involve the generation of soluble agonists.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1525-8882
pubmed:author
pubmed:issnType
Electronic
pubmed:day
18
pubmed:volume
2000
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
pe1
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
EGF receptor transactivation mediated by the proteolytic production of EGF-like agonists.
pubmed:affiliation
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232--0146, USA. graham.carpenter@mcmail.vanderbilt.edu
pubmed:publicationType
Journal Article, Review