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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-2-26
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pubmed:databankReference |
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pubmed:abstractText |
Epstein-Barr virus (EBV) causes infectious mononucleosis, establishes long-term latent infections, and is associated with a variety of human tumors. The EBV gp42 glycoprotein binds MHC class II molecules, playing a critical role in infection of B lymphocytes. EBV gp42 belongs to the C-type lectin superfamily, with homology to NK receptors of the immune system. We report the crystal structure of gp42 bound to the human MHC class II molecule HLA-DR1. The gp42 binds HLA-DR1 using a surface site that is distinct from the canonical lectin and NK receptor ligand binding sites. At the canonical ligand binding site, gp42 forms a large hydrophobic groove, which could interact with other ligands necessary for EBV entry, providing a mechanism for coupling MHC recognition and membrane fusion.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1097-2765
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
375-85
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11864610-Amino Acid Sequence,
pubmed-meshheading:11864610-Binding Sites,
pubmed-meshheading:11864610-Crystallization,
pubmed-meshheading:11864610-Crystallography, X-Ray,
pubmed-meshheading:11864610-Dimerization,
pubmed-meshheading:11864610-Glycoproteins,
pubmed-meshheading:11864610-HLA-DR1 Antigen,
pubmed-meshheading:11864610-Herpesvirus 4, Human,
pubmed-meshheading:11864610-Humans,
pubmed-meshheading:11864610-Lectins,
pubmed-meshheading:11864610-Membrane Fusion,
pubmed-meshheading:11864610-Models, Molecular,
pubmed-meshheading:11864610-Molecular Sequence Data,
pubmed-meshheading:11864610-Protein Binding,
pubmed-meshheading:11864610-Protein Conformation,
pubmed-meshheading:11864610-Protein Interaction Mapping,
pubmed-meshheading:11864610-Recombinant Fusion Proteins,
pubmed-meshheading:11864610-Sequence Alignment,
pubmed-meshheading:11864610-Sequence Homology, Amino Acid,
pubmed-meshheading:11864610-Viral Proteins
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pubmed:year |
2002
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pubmed:articleTitle |
Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1.
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pubmed:affiliation |
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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