Source:http://linkedlifedata.com/resource/pubmed/id/11862518
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2002-3-7
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pubmed:abstractText |
Photodynamic therapy (PDT) has been under discussion as additional treatment option for malignant gliomas. However, damage not only to tumour tissue but also to normal brain has been demonstrated. The mechanisms of this unwanted side effect have not yet been clearly identified. Spreading of photosensitiser with oedema after disruption of the blood-brain-barrier and potential sensitisation of normal tissue has been found previously. The present study investigates the time- and dose-dependency of normal tissue damage to photodynamic therapy using Photofrin II after disruption of the blood-brain-barrier.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0001-6268
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
144
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-9; discussion 179
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pubmed:dateRevised |
2009-11-11
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pubmed:meshHeading |
pubmed-meshheading:11862518-Animals,
pubmed-meshheading:11862518-Antineoplastic Agents,
pubmed-meshheading:11862518-Blood-Brain Barrier,
pubmed-meshheading:11862518-Brain,
pubmed-meshheading:11862518-Brain Neoplasms,
pubmed-meshheading:11862518-Dihematoporphyrin Ether,
pubmed-meshheading:11862518-Dose-Response Relationship, Drug,
pubmed-meshheading:11862518-Edema,
pubmed-meshheading:11862518-Light,
pubmed-meshheading:11862518-Male,
pubmed-meshheading:11862518-Necrosis,
pubmed-meshheading:11862518-Photochemotherapy,
pubmed-meshheading:11862518-Rats,
pubmed-meshheading:11862518-Rats, Wistar
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pubmed:year |
2002
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pubmed:articleTitle |
Experimental research photodynamic effects in perifocal, oedematous brain tissue.
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pubmed:affiliation |
Department of Neurosurgery, Ludwig-Maximilians-University of Munich, Marchioninstrasse 15, 81477 Munich, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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