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pubmed:abstractText |
Previously we have shown that a malignant mouse keratinocyte cell line, 10Gy5, has elevated AP-1 transactivation and reduced JunB protein levels compared to its parental benign cell line, 308, and that the tumorigenicity in the 10Gy5 cells could be blocked by a dominant negative c-Jun mutant protein. We wished to determine whether the change in JunB protein levels could account for the elevated AP-1 activity and whether re-expression of JunB in malignant 10Gy5 cells altered their proliferative capacity.
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pubmed:affiliation |
Department of Radiation Oncology, University of Arizona, Health Sciences Center, Rm. 4993, Arizona Cancer Center, 1515 N. Campbell, Tucson, AR 85724, USA.
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