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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-3-6
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pubmed:abstractText |
1. The influence of 5-hydroxytryptamine (5-HT) receptor agonists and antagonists on the ureter motility was investigated in vivo on intact ureters of anaesthetized pigs. Drugs were administered intravenously or topically. 2. 5-HT induced a dose-dependent increase in the frequency of ureter contractions in anaesthetized pigs when given intravenously (0.0001-1 mg kg(-1); ED(50) 0.066 mg kg(-1)) or topically (0.001-1 mg ml(-1); EC(50) 0.043 mg ml(-1)). Significant increases in heart rate and blood pressure were observed when the drug was given intravenously but not topically. 3. The 5-HT(2A) agonist, DOI (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) increased the frequency of ureteral contractions in a dose-dependent manner (1-300 microg kg(-1) i.v.). Calculation of ED(50) indicated this compound to be about 1.5 times more potent with an efficacy of 23% compared to 5-HT. 4. The 5-HT(2A/2C) antagonist, ketanserin (0.5 mg kg(-1)) and the 5-HT(2C) antagonist, methysergide (1 mg kg(-1)) antagonized the 5-HT-induced ureter peristalsis when given intravenously. Contraction amplitude, blood pressure and heart rate were not affected by the antagonists. 5. Intravenous (0.0001-1 mg kg(-1)) and topical (0.0001-1 microg ml(-1)) ketanserin significantly decreased the frequency of spontaneous ureteral contractions to about 30% of controls, which could be partly reversed by 5-HT (0.3 mg kg(-1) i.v.). The contraction amplitude, contractions of the contralateral, saline perfused ureter, heart rate and mean arterial blood pressure were not affected. 6. Thus, contractility of porcine ureter is mediated by 5-HT(2) receptors. Their antagonists ketanserin and methysergide seem to be promising drugs for treatment of acute ureteric colic or in preparing the ureter for ureteroscopy.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-10373245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-11458123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-204992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-2459510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-4151303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-4152083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-4316596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-5041447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-5928179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-6024101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-6126541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-6126575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-6182416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-6261070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-6283070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-6311738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-6834525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-8588266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-9016930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-9136143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11861331-9745358
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Indophenol,
http://linkedlifedata.com/resource/pubmed/chemical/Ketanserin,
http://linkedlifedata.com/resource/pubmed/chemical/Methysergide,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2C,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/dimethoxy-4-indophenyl-2-aminopropan...
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
135
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1026-32
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11861331-Animals,
pubmed-meshheading:11861331-Female,
pubmed-meshheading:11861331-Indophenol,
pubmed-meshheading:11861331-Ketanserin,
pubmed-meshheading:11861331-Male,
pubmed-meshheading:11861331-Methysergide,
pubmed-meshheading:11861331-Muscle, Smooth,
pubmed-meshheading:11861331-Muscle Contraction,
pubmed-meshheading:11861331-Receptor, Serotonin, 5-HT2A,
pubmed-meshheading:11861331-Receptor, Serotonin, 5-HT2C,
pubmed-meshheading:11861331-Receptors, Serotonin,
pubmed-meshheading:11861331-Serotonin,
pubmed-meshheading:11861331-Serotonin Antagonists,
pubmed-meshheading:11861331-Serotonin Receptor Agonists,
pubmed-meshheading:11861331-Swine,
pubmed-meshheading:11861331-Ureter
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pubmed:year |
2002
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pubmed:articleTitle |
Effects of ketanserin and DOI on spontaneous and 5-HT-evoked peristalsis of the pig ureter in vivo.
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pubmed:affiliation |
Institute of Veterinary Pharmacology, University of Bern, 3012 Bern, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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