Linked Life Data

1186124

Source:http://linkedlifedata.com/resource/pubmed/id/1186124

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1976-1-14
pubmed:abstractText
Mammary lobuloalveolar hyperplasia induced in rats by the administration of estradiol or progesterone did not evolve into advanced hyperplasia or cancer as was noted in animals that received these hormones and peroral instillations of methylcholanthrene. Although the early hyperplastic changes encountered in both groups were histologically indistinguishable, only cells from the lesions of the rats treated with methylcholanthrene and hormones exhibited significant numbers of aneuploid cells. This information indicates that, at least in the rat, not all instances of mammary hyperplasia possess the potential to develop into cancer. Chromosome analysis appears to represent a useful technique for the discrimination of these forms of hyperplasia. The significance of an appropriate inducer, i.e., methylcholanthrene, for the development of mammary carcinoma in this model system, as well as the well recognized proper hormonal milieu, is apparent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0023-6837
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
446-50
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Identification of premalignant hyperplasia in methylcholanthrene-induced mammary tumorogenesis.
pubmed:publicationType
Journal Article