| pubmed-article:11859850 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11859850 | lifeskim:mentions | umls-concept:C0033306 | lld:lifeskim |
| pubmed-article:11859850 | lifeskim:mentions | umls-concept:C0009905 | lld:lifeskim |
| pubmed-article:11859850 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:11859850 | lifeskim:mentions | umls-concept:C0584960 | lld:lifeskim |
| pubmed-article:11859850 | lifeskim:mentions | umls-concept:C0427579 | lld:lifeskim |
| pubmed-article:11859850 | lifeskim:mentions | umls-concept:C0441509 | lld:lifeskim |
| pubmed-article:11859850 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:11859850 | lifeskim:mentions | umls-concept:C0150312 | lld:lifeskim |
| pubmed-article:11859850 | lifeskim:mentions | umls-concept:C1689985 | lld:lifeskim |
| pubmed-article:11859850 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11859850 | pubmed:dateCreated | 2002-2-22 | lld:pubmed |
| pubmed-article:11859850 | pubmed:abstractText | Compared to second generation, the use of third generation oral contraceptives has been associated with an increased risk of venous thrombosis especially in women with the factor V Leiden mutation. To find an explanation for these risk differences we investigated the effects of desogestrel- and levonorgestrel-containing oral contraceptives as well as their progestagens separately on the coagulation system in the absence or presence of the factor V Leiden mutation. In a single center, double blind trial, 51 women without and 35 women with the factor V Leiden mutation were randomized to either a second generation (30 microg ethinylestradiol/150 microg levonorgestrel) or a third generation (30 microg ethinylestradiol/150 microg desogestrel) oral contraceptive. After two cycles of use and a wash-out period of 2 menstrual cycles, the participants received the corresponding progestagen-only preparation containing 150 microg levonorgestrel or 150 microg desogestrel. In plasmas of the participating women fragment 1+2, factor V, VII, VIII, IX, X and XI were determined. Both combined oral contraceptives induced a decrease in factor V, whereas the levels of all other coagulant parameters increased. However, in women without the factor V Leiden mutation the effects of desogestrel-containing preparations were significantly different compared to levonorgestrel-containing oral contraceptives for factor V (-8.0; 95% CI -13.4 to -2.6), factor VII (26.8; 95% CI 15.5 to 38.0) and factor IX (-9.6; 95% CI -16.2 to -3.2). When these women used progestagen-only pills, a differential effect between desogestrel and levonorgestrel was only found for factor IX (-6.5; 95% CI -11.4 to -1.5). In carriers of the factor V Leiden mutation desogestrel-containing oral contraceptives induced more pronounced changes in factor V (-14.2; 95% CI -22.4 to -6.0) and factor VII (36.1; 95% CI 19.7 to 52.6) compared to levonorgestrel-containing oral contraceptives. Comparing desogestrel- and levonorgestrel-only, only for factor V a differential effect was found in these women (-9.5; 95% CI -18.3 to -0.6). It appears that desogestrel-containing oral contraceptives have a more pronounced effect on the coagulation system than levonorgestrel-containing oral contraceptives which may be explained by a less effective compensation of the thrombotic effect of ethinylestradiol by desogestrel. | lld:pubmed |
| pubmed-article:11859850 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11859850 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11859850 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11859850 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11859850 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11859850 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11859850 | pubmed:issn | 0340-6245 | lld:pubmed |
| pubmed-article:11859850 | pubmed:author | pubmed-author:BoumaB NBN | lld:pubmed |
| pubmed-article:11859850 | pubmed:author | pubmed-author:AlgraAA | lld:pubmed |
| pubmed-article:11859850 | pubmed:author | pubmed-author:GrobbeeD EDE | lld:pubmed |
| pubmed-article:11859850 | pubmed:author | pubmed-author:KemmerenJ MJM | lld:pubmed |
| pubmed-article:11859850 | pubmed:author | pubmed-author:MeijersJ C... | lld:pubmed |
| pubmed-article:11859850 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11859850 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:11859850 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11859850 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11859850 | pubmed:pagination | 199-205 | lld:pubmed |
| pubmed-article:11859850 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11859850 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11859850 | pubmed:articleTitle | Effects of second and third generation oral contraceptives and their respective progestagens on the coagulation system in the absence or presence of the factor V Leiden mutation. | lld:pubmed |
| pubmed-article:11859850 | pubmed:affiliation | Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, The Netherlands. | lld:pubmed |
| pubmed-article:11859850 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11859850 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:11859850 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11859850 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:11859850 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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