Source:http://linkedlifedata.com/resource/pubmed/id/11859850
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2002-2-22
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| pubmed:abstractText |
Compared to second generation, the use of third generation oral contraceptives has been associated with an increased risk of venous thrombosis especially in women with the factor V Leiden mutation. To find an explanation for these risk differences we investigated the effects of desogestrel- and levonorgestrel-containing oral contraceptives as well as their progestagens separately on the coagulation system in the absence or presence of the factor V Leiden mutation. In a single center, double blind trial, 51 women without and 35 women with the factor V Leiden mutation were randomized to either a second generation (30 microg ethinylestradiol/150 microg levonorgestrel) or a third generation (30 microg ethinylestradiol/150 microg desogestrel) oral contraceptive. After two cycles of use and a wash-out period of 2 menstrual cycles, the participants received the corresponding progestagen-only preparation containing 150 microg levonorgestrel or 150 microg desogestrel. In plasmas of the participating women fragment 1+2, factor V, VII, VIII, IX, X and XI were determined. Both combined oral contraceptives induced a decrease in factor V, whereas the levels of all other coagulant parameters increased. However, in women without the factor V Leiden mutation the effects of desogestrel-containing preparations were significantly different compared to levonorgestrel-containing oral contraceptives for factor V (-8.0; 95% CI -13.4 to -2.6), factor VII (26.8; 95% CI 15.5 to 38.0) and factor IX (-9.6; 95% CI -16.2 to -3.2). When these women used progestagen-only pills, a differential effect between desogestrel and levonorgestrel was only found for factor IX (-6.5; 95% CI -11.4 to -1.5). In carriers of the factor V Leiden mutation desogestrel-containing oral contraceptives induced more pronounced changes in factor V (-14.2; 95% CI -22.4 to -6.0) and factor VII (36.1; 95% CI 19.7 to 52.6) compared to levonorgestrel-containing oral contraceptives. Comparing desogestrel- and levonorgestrel-only, only for factor V a differential effect was found in these women (-9.5; 95% CI -18.3 to -0.6). It appears that desogestrel-containing oral contraceptives have a more pronounced effect on the coagulation system than levonorgestrel-containing oral contraceptives which may be explained by a less effective compensation of the thrombotic effect of ethinylestradiol by desogestrel.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Coagulation Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Contraceptives, Oral, Combined,
http://linkedlifedata.com/resource/pubmed/chemical/Contraceptives, Oral, Hormonal,
http://linkedlifedata.com/resource/pubmed/chemical/Desogestrel,
http://linkedlifedata.com/resource/pubmed/chemical/Ethinyl Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Factor IX,
http://linkedlifedata.com/resource/pubmed/chemical/Factor V,
http://linkedlifedata.com/resource/pubmed/chemical/Factor VII,
http://linkedlifedata.com/resource/pubmed/chemical/Levonorgestrel,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Prothrombin,
http://linkedlifedata.com/resource/pubmed/chemical/factor V Leiden,
http://linkedlifedata.com/resource/pubmed/chemical/prothrombin fragment 1.2
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0340-6245
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
87
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
199-205
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11859850-Activated Protein C Resistance,
pubmed-meshheading:11859850-Adult,
pubmed-meshheading:11859850-Blood Coagulation,
pubmed-meshheading:11859850-Blood Coagulation Factors,
pubmed-meshheading:11859850-Contraceptives, Oral, Combined,
pubmed-meshheading:11859850-Contraceptives, Oral, Hormonal,
pubmed-meshheading:11859850-Desogestrel,
pubmed-meshheading:11859850-Double-Blind Method,
pubmed-meshheading:11859850-Ethinyl Estradiol,
pubmed-meshheading:11859850-Factor IX,
pubmed-meshheading:11859850-Factor V,
pubmed-meshheading:11859850-Factor VII,
pubmed-meshheading:11859850-Female,
pubmed-meshheading:11859850-Humans,
pubmed-meshheading:11859850-Levonorgestrel,
pubmed-meshheading:11859850-Peptide Fragments,
pubmed-meshheading:11859850-Prothrombin,
pubmed-meshheading:11859850-Thrombophilia
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| pubmed:year |
2002
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| pubmed:articleTitle |
Effects of second and third generation oral contraceptives and their respective progestagens on the coagulation system in the absence or presence of the factor V Leiden mutation.
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| pubmed:affiliation |
Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, The Netherlands.
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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