11859001

Source:http://linkedlifedata.com/resource/pubmed/id/11859001

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0220781, umls-concept:C0387583, umls-concept:C0441655, umls-concept:C1289971, umls-concept:C1527240, umls-concept:C1554184, umls-concept:C1883254
pubmed:issue	5
pubmed:dateCreated	2002-2-22
pubmed:abstractText	Dual COX-2/5-LO inhibitors are described as potential new therapeutic agents for inflammatory diseases. A surprisingly potent effect of a 5-LO pharmacophoric group on the COX-2 inhibition is presented as well as pharmacological in vitro and in vivo results.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone, http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes, http://linkedlifedata.com/resource/pubmed/chemical/Lipoxygenase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases, http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles, http://linkedlifedata.com/resource/pubmed/chemical/Sulfones
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	0960-894X
pubmed:author	pubmed-author:BarbeySabineS, pubmed-author:CharlierCarolineC, pubmed-author:ChoesmelValérieV, pubmed-author:CornetJoséphineJ, pubmed-author:GimenoGillesG, pubmed-author:GoossensLaurenceL, pubmed-author:HénichartJean PierreJP, pubmed-author:HoussinRaymondR, pubmed-author:MichauxCatherineC, pubmed-author:RouaudCélineC, pubmed-author:TaverneThierryT, pubmed-author:Yannic-ArnoultSylvieS
pubmed:issnType	Print
pubmed:day	11
pubmed:volume	12
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	779-82
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:11859001-Animals, pubmed-meshheading:11859001-Cells, Cultured, pubmed-meshheading:11859001-Cyclooxygenase 2, pubmed-meshheading:11859001-Cyclooxygenase 2 Inhibitors, pubmed-meshheading:11859001-Cyclooxygenase Inhibitors, pubmed-meshheading:11859001-Dinoprostone, pubmed-meshheading:11859001-Granulocytes, pubmed-meshheading:11859001-Inhibitory Concentration 50, pubmed-meshheading:11859001-Isoenzymes, pubmed-meshheading:11859001-Lipoxygenase Inhibitors, pubmed-meshheading:11859001-Male, pubmed-meshheading:11859001-Monocytes, pubmed-meshheading:11859001-Osteosarcoma, pubmed-meshheading:11859001-Prostaglandin-Endoperoxide Synthases, pubmed-meshheading:11859001-Pyrazoles, pubmed-meshheading:11859001-Rats, pubmed-meshheading:11859001-Rats, Wistar, pubmed-meshheading:11859001-Structure-Activity Relationship, pubmed-meshheading:11859001-Sulfones
pubmed:year	2002
pubmed:articleTitle	Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.
pubmed:affiliation	Laboratoires Innothera, avenue P. Vaillant-Couturier, BP 10, 94110, Arcueil, France.
pubmed:publicationType	Journal Article, Comparative Study