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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-2-22
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pubmed:abstractText |
Fractionation of a methanol extract of the leaves and twigs of Casearia sylvestris, as directed by activity against KB cell cytotoxicity, led to the isolation of three novel clerodane diterpenoids, casearvestrins A-C (1-3). The structures of 1-3 were deduced from one- and two-dimensional NMR experiments, including relative stereochemical assignments based on ROESY correlations and COSY coupling constants. All three compounds displayed promising bioactivity, both in cytotoxicity assays against a panel of tumor cell lines and in antifungal assays via the growth inhibition of Aspergillus niger in a disk diffusion assay.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0163-3864
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pubmed:author |
pubmed-author:BurgessJason PJP,
pubmed-author:FairchildCraig RCR,
pubmed-author:FarnsworthNorman RNR,
pubmed-author:KinghornA DouglasAD,
pubmed-author:NavarroHernán AHA,
pubmed-author:OberliesNicholas HNH,
pubmed-author:PetersonRussell WRW,
pubmed-author:PinosRosa ElenaRE,
pubmed-author:SoejartoDjaja DDD,
pubmed-author:WallMonroe EME,
pubmed-author:WaniMansukh CMC
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pubmed:issnType |
Print
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
95-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11858737-Angiosperms,
pubmed-meshheading:11858737-Antifungal Agents,
pubmed-meshheading:11858737-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:11858737-Aspergillus niger,
pubmed-meshheading:11858737-Colonic Neoplasms,
pubmed-meshheading:11858737-Diterpenes,
pubmed-meshheading:11858737-Drug Screening Assays, Antitumor,
pubmed-meshheading:11858737-Ecuador,
pubmed-meshheading:11858737-Female,
pubmed-meshheading:11858737-Humans,
pubmed-meshheading:11858737-Inhibitory Concentration 50,
pubmed-meshheading:11858737-KB Cells,
pubmed-meshheading:11858737-Lung Neoplasms,
pubmed-meshheading:11858737-Molecular Conformation,
pubmed-meshheading:11858737-Molecular Structure,
pubmed-meshheading:11858737-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:11858737-Ovarian Neoplasms,
pubmed-meshheading:11858737-Plant Leaves,
pubmed-meshheading:11858737-Plant Shoots,
pubmed-meshheading:11858737-Plants, Medicinal,
pubmed-meshheading:11858737-Spectrophotometry, Infrared,
pubmed-meshheading:11858737-Spectrophotometry, Ultraviolet,
pubmed-meshheading:11858737-Spectroscopy, Fourier Transform Infrared,
pubmed-meshheading:11858737-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris.
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pubmed:affiliation |
Chemistry and Life Sciences, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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