Linked Life Data

11857907

Source:http://linkedlifedata.com/resource/pubmed/id/11857907

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-2-22
pubmed:abstractText
Various actions of steroids, thyroid, vitamin D and retinoic acid are mediated by cognate nuclear hormone receptors. Hormone-liganded receptors bind to hormone response element in transcription regulatory region and homodimerize or heterodimerize with retinoid X receptor and regulate transcription of target genes. Conformational change of nuclear receptor after ligand-binding gives association with coactivators which possess histone acetyltransferase activity and are necessary for hormone-dependent transactivation. In the absence of hormone, corepressors, which associate with histone deacetyltransferase, interact to nuclear hormone receptors and repress the transcription. All these factors have important roles in the signaling of nuclear receptor and may be involved in endocrine dysfunction and disease.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
230-6
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
[Molecular mechanism of hormone-dependent transcriptional regulation of nuclear receptor].
pubmed:affiliation
Research Center for Genomic Medicine, Saitama Medical School.
pubmed:publicationType
Journal Article, English Abstract, Review