Linked Life Data

11856573

Source:http://linkedlifedata.com/resource/pubmed/id/11856573

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-3-7
pubmed:abstractText
It has been thoroughly established that the fungicide vinclozolin and the persistent DDT metabolite p,p'-DDE, can function as antiandrogens in mammals in a manner similar to the therapeutic antiandrogen flutamide. In mammals, these chemicals bind the androgen receptor and prevent the transcription of the associated genes causing abnormal sexual development and demasculinization. There are few similar studies in fish and so far it has not been demonstrated that these chemicals have any antiandrogenic effects in this group. In the present study, juvenile guppies (Poecilia reticulata) were fed sublethal doses of vinclozolin, p,p'-DDE or flutamide from birth to adulthood. At sexual maturity, we measured a suite of male sexual characteristics that are known to be under androgen control. All three chemicals caused a reduction in the orange display coloration, inhibited gonopodium development, reduced the sperm count and suppressed courtship behaviour, in a manner consistent with antiandrogen action. Only the gonodosomatic index was unaffected by the treatments. In addition, the three chemicals skewed the sex ratio at adulthood and caused delayed maturation. The altered characters are all considered to be important for male mating success and their impairment indicates that antiandrogens may seriously compromise male reproductive fitness.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0166-445X
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
227-39
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Exposure of juvenile guppies to three antiandrogens causes demasculinization and a reduced sperm count in adult males.
pubmed:affiliation
Department of Zoology, Institute of Biological Sciences, University of Aarhus, Aarhus, Denmark. mark.bayley@biology.au.dk
pubmed:publicationType
Journal Article