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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-2-20
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pubmed:abstractText |
Alternative splicing of the gene for Stat3, a transcription factor activated by the IL-6 family of cytokines, produces two isoforms: Stat3alpha and a dominant-negative variant, Stat3beta. Stat3beta-deficient mice were generated by gene targeting. Despite intact expression and phosphorylation of Stat3alpha, overall Stat3 activity was impaired in Stat3beta(-/-) cells. Global comparison of transcription in Stat3beta(+/+) and Stat3beta(-/-) cells revealed stable differences. Stat3beta-deficient mice exhibit diminished recovery from endotoxic shock and hyperresponsiveness of a subset of endotoxin-inducible genes in liver. The hepatic response to endotoxin in wild-type mice is accompanied by a transient increase in the ratio of Stat3beta to Stat3alpha. These findings indicate a critical role for Stat3beta in the control of systemic inflammation.
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pubmed:keyword |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
331-44
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11853668-Acute-Phase Proteins,
pubmed-meshheading:11853668-Alternative Splicing,
pubmed-meshheading:11853668-Amino Acid Sequence,
pubmed-meshheading:11853668-Animals,
pubmed-meshheading:11853668-Base Sequence,
pubmed-meshheading:11853668-DNA-Binding Proteins,
pubmed-meshheading:11853668-Endotoxins,
pubmed-meshheading:11853668-Liver,
pubmed-meshheading:11853668-Mice,
pubmed-meshheading:11853668-Mice, Knockout,
pubmed-meshheading:11853668-Molecular Sequence Data,
pubmed-meshheading:11853668-Protein Isoforms,
pubmed-meshheading:11853668-STAT3 Transcription Factor,
pubmed-meshheading:11853668-Shock, Septic,
pubmed-meshheading:11853668-Trans-Activators,
pubmed-meshheading:11853668-Transcriptional Activation
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pubmed:year |
2002
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pubmed:articleTitle |
Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock.
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pubmed:affiliation |
Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Baltimore, MD, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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