Source:http://linkedlifedata.com/resource/pubmed/id/11850769
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2002-2-18
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| pubmed:abstractText |
A relation between left ventricular (LV) hypertrophy and depressed midwall systolic function has been described in hypertensive subjects. However, a strong confounding factor in this relation is concentric geometry, which is both a powerful determinant of depressed midwall systolic function and a correlate of LV mass in hypertension. To evaluate the independent contribution of LV mass to depressed systolic function, 1827 patients with never-treated essential hypertension (age 48 +/- 12 years, men 58%) underwent M-mode echocardiography under two-dimensional guidance. Relative wall thickness was the strongest determinant of low midwall fractional shortening (r = -0.63, P < 0.0001). The significant inverse relation observed between LV mass and midwall fractional shortening (r = -0.43, P < 0.0001) persisted after taking into account the effect of relative wall thickness (partial r = -0.27, P < 0.0001). Within each sex-specific quintile of relative wall thickness, prevalence of subnormal afterload-corrected midwall systolic function was greater in subjects with, than in subjects without, LV hypertrophy (P < 0.05 for the first, third, fourth and fifth quintile). In a multiple linear regression analysis, both LV mass (P < 0.0001) and relative wall thickness (P < 0.0001) were independent predictors of a reduced midwall fractional shortening. In conclusion, the inverse association between LV mass and midwall systolic function is partly independent from the effect of relative wall thickness. LV hypertrophy is a determinant of subclinical LV dysfunction independently of the concomitant changes in chamber geometry.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0950-9240
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
16
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
117-22
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11850769-Adult,
pubmed-meshheading:11850769-Age Distribution,
pubmed-meshheading:11850769-Aged,
pubmed-meshheading:11850769-Blood Pressure Determination,
pubmed-meshheading:11850769-Case-Control Studies,
pubmed-meshheading:11850769-Cohort Studies,
pubmed-meshheading:11850769-Comorbidity,
pubmed-meshheading:11850769-Confidence Intervals,
pubmed-meshheading:11850769-Confounding Factors (Epidemiology),
pubmed-meshheading:11850769-Echocardiography,
pubmed-meshheading:11850769-Female,
pubmed-meshheading:11850769-Heart Function Tests,
pubmed-meshheading:11850769-Humans,
pubmed-meshheading:11850769-Hypertension,
pubmed-meshheading:11850769-Hypertrophy, Left Ventricular,
pubmed-meshheading:11850769-Italy,
pubmed-meshheading:11850769-Male,
pubmed-meshheading:11850769-Middle Aged,
pubmed-meshheading:11850769-Prevalence,
pubmed-meshheading:11850769-Reference Values,
pubmed-meshheading:11850769-Risk Assessment,
pubmed-meshheading:11850769-Risk Factors,
pubmed-meshheading:11850769-Severity of Illness Index,
pubmed-meshheading:11850769-Sex Distribution,
pubmed-meshheading:11850769-Systole,
pubmed-meshheading:11850769-Ventricular Dysfunction, Left
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| pubmed:year |
2002
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| pubmed:articleTitle |
Left ventricular mass and systolic dysfunction in essential hypertension.
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| pubmed:affiliation |
Unit of Internal Medicine, Angiology and Arteriosclerosis, University of Perugia, Italy. skill@unipg.it
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| pubmed:publicationType |
Journal Article
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