|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2002-2-18
|
|
pubmed:abstractText |
Mutation of the ATM gene may be associated with enhanced radiosensitivity and increased radiation-induced morbidity. Denaturing high performance liquid chromatography (DHPLC) is a powerful new technique proven to be sensitive and accurate in the detection of missense mutations, as well as small deletions and insertions. We screened female breast cancer patients for evidence of ATM gene alterations using DHPLC. This study attempted to determine whether breast cancer patients who develop severe radiotherapy (RT)-induced effects are more likely to possess ATM mutations than patients who display normal radiation responses.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0360-3016
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
52
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
606-13
|
|
pubmed:dateRevised |
2011-11-2
|
|
pubmed:meshHeading |
pubmed-meshheading:11849780-Adult,
pubmed-meshheading:11849780-Aged,
pubmed-meshheading:11849780-Aged, 80 and over,
pubmed-meshheading:11849780-Breast Neoplasms,
pubmed-meshheading:11849780-Cell Cycle Proteins,
pubmed-meshheading:11849780-Chromatography, High Pressure Liquid,
pubmed-meshheading:11849780-DNA-Binding Proteins,
pubmed-meshheading:11849780-Female,
pubmed-meshheading:11849780-Humans,
pubmed-meshheading:11849780-Middle Aged,
pubmed-meshheading:11849780-Mutation,
pubmed-meshheading:11849780-Neoplasm Staging,
pubmed-meshheading:11849780-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11849780-Radiation Tolerance,
pubmed-meshheading:11849780-Radiodermatitis,
pubmed-meshheading:11849780-Retrospective Studies,
pubmed-meshheading:11849780-Tumor Suppressor Proteins
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
ATM mutations in female breast cancer patients predict for an increase in radiation-induced late effects.
|
|
pubmed:affiliation |
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA. christopher.iannuzzi@mountsinai.org
|
|
pubmed:publicationType |
Journal Article
|
