Linked Life Data

11849739

Source:http://linkedlifedata.com/resource/pubmed/id/11849739

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-3-7
pubmed:abstractText
Hypohalites (OCl-, OBr-) are formed at inflammation sites as antimicrobial agents. OCl- is also used for the disinfection of water supplies and the association of drinking chlorinated water with cancer risk is pointed out. In this study, OCl- itself induced 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) formation, while OBr- damaged DNA only when glutathione (GSH) was added. OCl- caused oxidative DNA damage more efficiently than OBr-/GSH. In experiment with 32P-labeled DNA fragments, OCl- strongly caused piperidine-labile sites at guanine residues than piperidine-inert 8-oxodG, whereas OBr-/GSH caused no piperidine-labile sites. Endogenous OCl- may play a role in genotoxicity close to the site of inflammation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/8-oxo-7-hydrodeoxyguanosine, http://linkedlifedata.com/resource/pubmed/chemical/Bromates, http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens, http://linkedlifedata.com/resource/pubmed/chemical/DNA, http://linkedlifedata.com/resource/pubmed/chemical/Deoxyguanosine, http://linkedlifedata.com/resource/pubmed/chemical/Dimethyl Sulfoxide, http://linkedlifedata.com/resource/pubmed/chemical/Glutathione, http://linkedlifedata.com/resource/pubmed/chemical/Phosphorus Isotopes, http://linkedlifedata.com/resource/pubmed/chemical/Piperidines, http://linkedlifedata.com/resource/pubmed/chemical/Sodium Hypochlorite, http://linkedlifedata.com/resource/pubmed/chemical/hypobromous acid, http://linkedlifedata.com/resource/pubmed/chemical/piperidine
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0304-3835
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
178
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-42
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:11849739-Animals, pubmed-meshheading:11849739-Bromates, pubmed-meshheading:11849739-Carcinogens, pubmed-meshheading:11849739-Cattle, pubmed-meshheading:11849739-Cell Line, pubmed-meshheading:11849739-DNA, pubmed-meshheading:11849739-DNA Damage, pubmed-meshheading:11849739-Deoxyguanosine, pubmed-meshheading:11849739-Dimethyl Sulfoxide, pubmed-meshheading:11849739-Electron Spin Resonance Spectroscopy, pubmed-meshheading:11849739-Genes, Tumor Suppressor, pubmed-meshheading:11849739-Genes, p53, pubmed-meshheading:11849739-Genes, ras, pubmed-meshheading:11849739-Glutathione, pubmed-meshheading:11849739-Humans, pubmed-meshheading:11849739-Inflammation, pubmed-meshheading:11849739-Neoplasms, pubmed-meshheading:11849739-Oxidation-Reduction, pubmed-meshheading:11849739-Phosphorus Isotopes, pubmed-meshheading:11849739-Piperidines, pubmed-meshheading:11849739-Sodium Hypochlorite
pubmed:year
2002
pubmed:articleTitle
DNA damage induced by hypochlorite and hypobromite with reference to inflammation-associated carcinogenesis.
pubmed:affiliation
Department of Hygiene, Mie University School of Medicine, 2-174, Edobashi, Tsu, Mie 514-8507, Japan.
pubmed:publicationType
Journal Article