rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-2-18
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pubmed:abstractText |
Over 54 generations, we have successfully bred a strain of rats that maximizes urinary calcium excretion. The rats now consistently excrete 8 to 10 times as much calcium as controls, uniformly form poorly crystalline calcium phosphate kidney stones, and are termed genetic hypercalciuric stone-forming (GHS) rats. These rats were used to test the hypothesis that increasing urinary oxalate excretion would not only increase the supersaturation with respect to the calcium oxalate solid phase, but also would increase the ratio of calcium oxalate-to-calcium phosphate supersaturation and result in calcium oxalate stone formation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
pubmed:issn |
0085-2538
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
975-87
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11849452-Animals,
pubmed-meshheading:11849452-Calcium,
pubmed-meshheading:11849452-Calcium Oxalate,
pubmed-meshheading:11849452-Calcium Phosphates,
pubmed-meshheading:11849452-Diet,
pubmed-meshheading:11849452-Diuresis,
pubmed-meshheading:11849452-Hydrogen-Ion Concentration,
pubmed-meshheading:11849452-Hydroxyproline,
pubmed-meshheading:11849452-Ions,
pubmed-meshheading:11849452-Kidney,
pubmed-meshheading:11849452-Kidney Calculi,
pubmed-meshheading:11849452-Male,
pubmed-meshheading:11849452-Microscopy, Electron, Scanning,
pubmed-meshheading:11849452-Rats,
pubmed-meshheading:11849452-Rats, Sprague-Dawley,
pubmed-meshheading:11849452-Urine
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pubmed:year |
2002
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pubmed:articleTitle |
Calcium oxalate stone formation in genetic hypercalciuric stone-forming rats.
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pubmed:affiliation |
Department of Medicine, Nephrology Unit, University of Rochester School of Medicine, Strong Memorial Hospital, 601 Elmwood Avenue, Rochester, NY 14642, USA. David.Bushinsky@URMC.Rochester.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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