Linked Life Data

11848466

Source:http://linkedlifedata.com/resource/pubmed/id/11848466

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2002-2-18
pubmed:abstractText
The kallikrein gene family is comprised of genes that have either established or potential applications in prostate and breast cancer diagnostics. New members of the human kallikrein gene family have been recently identified. By using the positional candidate gene approach, we were able to clone a novel human serine protease gene that maps to chromosome 19q13.3-q13.4, the location of the kallikrein gene family. We named this gene KLK-L4 (now also known as KLK13). Here, we describe the identification of five new KLK-L4 splice variants which are not expressed in any other tissue except the human testis. We have further established that these splice variants can be detected in normal testis but not in the adjacent matched testicular tumors. In addition, differential expression of the KLK-L4 gene was found in various histological types of testicular cancer. Our results suggest that the KLK-L4 gene is expressed in normal and cancerous testicular tissue; however, its five variants are all expressed in normal tissue but not in testicular tumors. The physiological relevance of these variants and the implications of their differential expression between cancerous and normal tissues are currently unknown.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3147-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Identification and molecular characterization of five novel kallikrein gene 13 (KLK13; KLK-L4) splice variants: differential expression in the human testis and testicular cancer.
pubmed:affiliation
Department of Pathology and Laboratoty Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't