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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5558
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pubmed:dateCreated |
2002-2-15
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pubmed:abstractText |
The Nedd8 ubiquitin-like protein modification pathway regulates cell-cycle progression. Our analysis of Nedd8 requirements during Caenorhabditis elegans embryogenesis indicates that the cytoskeleton is another target. Nedd8 conjugation negatively regulated contractility of the microfilament-rich cell cortex during pronuclear migration and again during cytokinesis. The Nedd8 pathway also was required after meiosis to negatively regulate katanin, a microtubule-severing complex, permitting the assembly of a large mitotic spindle. We propose that Nedd8-modified cullin, as part of an E3 ubiquitin ligase complex, targets katanin for degradation during the transition from meiosis to mitosis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/CUL2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CUL3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cullin Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MEI-1 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Nocodazole,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Helminth,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitins,
http://linkedlifedata.com/resource/pubmed/chemical/katanin
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
295
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1294-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11847342-Actin Cytoskeleton,
pubmed-meshheading:11847342-Adenosine Triphosphatases,
pubmed-meshheading:11847342-Animals,
pubmed-meshheading:11847342-Caenorhabditis elegans,
pubmed-meshheading:11847342-Caenorhabditis elegans Proteins,
pubmed-meshheading:11847342-Cell Cycle Proteins,
pubmed-meshheading:11847342-Cell Division,
pubmed-meshheading:11847342-Cell Membrane,
pubmed-meshheading:11847342-Cell Nucleus,
pubmed-meshheading:11847342-Cullin Proteins,
pubmed-meshheading:11847342-Embryo, Nonmammalian,
pubmed-meshheading:11847342-Genes, Helminth,
pubmed-meshheading:11847342-Meiosis,
pubmed-meshheading:11847342-Microtubules,
pubmed-meshheading:11847342-Mitosis,
pubmed-meshheading:11847342-Mitotic Spindle Apparatus,
pubmed-meshheading:11847342-Mutation,
pubmed-meshheading:11847342-Nocodazole,
pubmed-meshheading:11847342-RNA, Helminth,
pubmed-meshheading:11847342-Ubiquitins
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pubmed:year |
2002
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pubmed:articleTitle |
Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway.
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pubmed:affiliation |
Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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