Linked Life Data

11846432

Source:http://linkedlifedata.com/resource/pubmed/id/11846432

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-3-6
pubmed:abstractText
The synthesis, in vitro anti-HIV activity and stability studies of the 5'-fluorophosphate derivative of 3'-azido-3'-deoxythymidine (AZT) are reported. The results support the hypothesis that this phosphorylated entity exerts its biological effect via the delivery of the corresponding 5'-mononucleotide through an enzymatic process. However, the antiviral evaluation in thymidine kinase-deficient CEM cells as well as the stability studies in culture medium and cell extract showed that this bioconversion is not specific to the intracellular medium. Attempts to improve the biological activity of mononucleoside 5'-fluorophosphates by the use of the S-pivaloyl-2-thioethyl (tBuSATE) group as biolabile phosphate protection are reported.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0045-2068
pubmed:author
pubmed:copyrightInfo
Copyright 2001 Elsevier Science (USA).
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
333-44
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Synthesis, anti-HIV activity, and stability studies of 5'-phosphorofluoridate derivatives of AZT.
pubmed:affiliation
UMR CNRS 5625, Université Montpellier II, cc 008, Place E. Bataillon, Montpellier Cedex 5, 34095, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't