Linked Life Data

11845246

Source:http://linkedlifedata.com/resource/pubmed/id/11845246

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-3-6
pubmed:abstractText
In an effort to establish distinct phylogenetic values for the major GABA(A) receptor subunit mRNAs (alpha(1), beta(2) and gamma(2)) in the telencephalon, the cellular expression capacity of these mRNAs was evaluated in this brain region of two distantly related mammals (hedgehog and rat). Application of emulsion hybridization histochemistry and quantitative film autoradiography approaches allowed us to detect elevated ( P<0.01) beta(2) mRNA levels in primitive telencephalic neuronal populations such as those of the glomerular olfactory layer of the hedgehog. Conversely, notable levels of the alpha(1)-subunit mRNA were also registered for the higher telencephalic regions such as the oriens-pyramidalis layer of the hippocampus although elevated levels were mostly obtained for the rat. Interestingly, it was the high number of giant pyramidal neurons that were actively involved in the expression of this subunit. A similar pattern was also detected for pyramidal-like cells of the rat lateral amygdala region expressing the gamma(2)-subunit mRNA. Taken together, these results suggest an early phylogenetic success of GABAergic neuronal mechanisms relying mainly on elevated beta(2)-subunit levels. On the other hand, elevated quantities of gamma(2)- and, above all, of alpha(1)-subunit mRNAs in the rat seem instead to be related to the highly advanced behavioral and mnemonic strategies that are under the control of these telencephalic regions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0014-4819
pubmed:author
pubmed:issnType
Print
pubmed:volume
142
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
504-11
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Early phylogenetic value of the major GABA(A) receptor subunit mRNAs in the telencephalon.
pubmed:affiliation
Comparative Anatomy Laboratory, Ecology Department, University of Calabria, 87030 Arcavacata di Rende, Cosenza, Italy.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't