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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-2-14
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pubmed:abstractText |
Dendritic cells (DCs) are specialized cells of the immune system that are capable of generating potent immune responses that are active even within the "immunologically privileged" central nervous system. However, immune responses generated by DCs have also been demonstrated to produce clinically significant autoimmunity. Targeting the epidermal growth factor receptor variant III (EGFRvIII), which is a mutation specific to tumor tissue, could eliminate this risk. The purpose of this study was to demonstrate that DC-based immunizations directed solely against this tumor-specific antigen, which is commonly found on tumors that originate within or metastasize to the brain, could be efficacious.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0148-396X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
158-64; discussion 164-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11844246-Animals,
pubmed-meshheading:11844246-Brain Neoplasms,
pubmed-meshheading:11844246-Cancer Vaccines,
pubmed-meshheading:11844246-Dendritic Cells,
pubmed-meshheading:11844246-Epitopes,
pubmed-meshheading:11844246-Male,
pubmed-meshheading:11844246-Melanoma, Experimental,
pubmed-meshheading:11844246-Mice,
pubmed-meshheading:11844246-Mice, Inbred C3H,
pubmed-meshheading:11844246-Mutation,
pubmed-meshheading:11844246-Neoplasm Transplantation,
pubmed-meshheading:11844246-Receptor, Epidermal Growth Factor,
pubmed-meshheading:11844246-Tumor Cells, Cultured,
pubmed-meshheading:11844246-Vaccines, Subunit
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pubmed:year |
2002
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pubmed:articleTitle |
Dendritic cells pulsed with a tumor-specific peptide induce long-lasting immunity and are effective against murine intracerebral melanoma.
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pubmed:affiliation |
Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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