|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001721,
umls-concept:C0006104,
umls-concept:C0020443,
umls-concept:C0030705,
umls-concept:C0032105,
umls-concept:C0074554,
umls-concept:C0086418,
umls-concept:C0208133,
umls-concept:C0301630,
umls-concept:C0332120,
umls-concept:C0441889,
umls-concept:C1156530
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2002-2-14
|
|
pubmed:abstractText |
Previous studies have shown that patients with early onset of Alzheimer disease and vascular dementia have higher levels of circulating brain-derived 24S-hydroxycholesterol (cerebrosterol). Two recent epidemiological studies indicated that treatment with inhibitors of cholesterol synthesis (statins) reduces the incidence of Alzheimer disease.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0003-9942
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
59
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
213-6
|
|
pubmed:dateRevised |
2009-11-3
|
|
pubmed:meshHeading |
pubmed-meshheading:11843691-Administration, Oral,
pubmed-meshheading:11843691-Adult,
pubmed-meshheading:11843691-Aged,
pubmed-meshheading:11843691-Alzheimer Disease,
pubmed-meshheading:11843691-Anticholesteremic Agents,
pubmed-meshheading:11843691-Brain,
pubmed-meshheading:11843691-Cholesterol,
pubmed-meshheading:11843691-Female,
pubmed-meshheading:11843691-Humans,
pubmed-meshheading:11843691-Hydroxycholesterols,
pubmed-meshheading:11843691-Hypercholesterolemia,
pubmed-meshheading:11843691-Male,
pubmed-meshheading:11843691-Middle Aged,
pubmed-meshheading:11843691-Prospective Studies,
pubmed-meshheading:11843691-Simvastatin
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain.
|
|
pubmed:affiliation |
Department of Clinical Pharmacology, Universitätsklinikum, University of Bonn, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|
