Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-2-20
pubmed:abstractText
Differentiation of spermatids into spermatozoa is regulated via phosphorylated RNA-binding proteins that modulate the expression of stage-specific mRNAs. We demonstrate that the phosphoserine, -threonine or -tyrosine, interaction protein, Styx, complexes with a testicular RNA-binding protein and is essential for normal spermiogenesis. Ablation of Styx expression in mouse disrupts round and elongating spermatid development, resulting in a >1,000-fold decrease in spermatozoa production. Moreover, Styx(-/-) males are infertile because of structural head abnormalities in residual epididymal sperm. Immunoprecipitation of Styx with Crhsp-24, a phosphorylated RNA-binding protein implicated in translational repression of histone mRNAs, provides a strategy for regulating posttranscriptional gene expression.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-10084927, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-10350128, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-10369260, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-10446180, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-10471512, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-10498891, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-10567663, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-10573413, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-10644438, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-10647936, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-10654943, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-10923677, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-13402725, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-7544315, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-7545337, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-7592916, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-8378314, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-8600390, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-8600391, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-8601034, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-8618919, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-8940251, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-9211421, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-9230311, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-9241420, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-9537407, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-9687511, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-9712905, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-9723004, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-9733578, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-9757831, http://linkedlifedata.com/resource/pubmed/commentcorrection/11842224-9882500
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2112-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:11842224-Animals, pubmed-meshheading:11842224-Blotting, Northern, pubmed-meshheading:11842224-Blotting, Western, pubmed-meshheading:11842224-Carrier Proteins, pubmed-meshheading:11842224-DNA-Binding Proteins, pubmed-meshheading:11842224-Genetic Vectors, pubmed-meshheading:11842224-Humans, pubmed-meshheading:11842224-Male, pubmed-meshheading:11842224-Mice, pubmed-meshheading:11842224-Mice, Inbred C57BL, pubmed-meshheading:11842224-Models, Genetic, pubmed-meshheading:11842224-Phosphoproteins, pubmed-meshheading:11842224-Phosphorylation, pubmed-meshheading:11842224-Plasmids, pubmed-meshheading:11842224-Precipitin Tests, pubmed-meshheading:11842224-Protein Structure, Tertiary, pubmed-meshheading:11842224-RNA, pubmed-meshheading:11842224-RNA Processing, Post-Transcriptional, pubmed-meshheading:11842224-Spermatogenesis, pubmed-meshheading:11842224-Spermatozoa, pubmed-meshheading:11842224-Testis, pubmed-meshheading:11842224-Transcription Factors
pubmed:year
2002
pubmed:articleTitle
The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production.
pubmed:affiliation
Life Sciences Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't