Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-2-13
pubmed:abstractText
Regional differences in the ontogeny of mouse intestinal alpha-2,6-sialyltransferase activities (alpha-2,6-ST) and the influence of cortisone acetate (CA) on this expression were determined. High ST activity and alpha-2,6-ST mRNA levels were detected in immature small and large intestine, with activity increasing distally from the duodenum. As the mice matured, ST activity (predominantly alpha-2,6-ST) in the small intestine decreased rapidly to adult levels by the fourth postnatal week. CA precociously accelerated this region-specific ontogenic decline. A similar decline of ST mRNA levels reflected ST activity in the small, but not the large, intestine. Small intestinal sialyl alpha-2,6-linked glycoconjugates displayed similar developmental and CA induced-precocious declines when probed using Sambucus nigra agglutinin (SNA) lectin. SNA labeling demonstrated age-dependent diminished sialyl alpha2,6 glycoconjugate expression in goblet cells in the small (but not large) intestine, but no such regional specificity was apparent in microvillus membrane. This suggests differential regulation of sialyl alpha-2,6 glycoconjugates in absorptive vs. globlet cells. These age-dependent and region-specific differences in sialyl alpha-2,6 glycoconjugates may be mediated in part by altered alpha-2,6-ST gene expression regulated by trophic factors such as glucocorticoids.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Asialoglycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Cortisone, http://linkedlifedata.com/resource/pubmed/chemical/Fetuins, http://linkedlifedata.com/resource/pubmed/chemical/Fluorescein-5-isothiocyanate, http://linkedlifedata.com/resource/pubmed/chemical/Fluorescent Dyes, http://linkedlifedata.com/resource/pubmed/chemical/Glycoconjugates, http://linkedlifedata.com/resource/pubmed/chemical/Lectins, http://linkedlifedata.com/resource/pubmed/chemical/N-Acetylneuraminic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Plant Lectins, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Ribosome Inactivating Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Sambucus nigra lectins, http://linkedlifedata.com/resource/pubmed/chemical/Sialyltransferases, http://linkedlifedata.com/resource/pubmed/chemical/alpha-Fetoproteins, http://linkedlifedata.com/resource/pubmed/chemical/asialofetuin
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0193-1857
pubmed:author
pubmed:issnType
Print
pubmed:volume
282
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
G480-90
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:11841998-Aging, pubmed-meshheading:11841998-Animals, pubmed-meshheading:11841998-Animals, Suckling, pubmed-meshheading:11841998-Asialoglycoproteins, pubmed-meshheading:11841998-Carbohydrate Conformation, pubmed-meshheading:11841998-Colon, pubmed-meshheading:11841998-Cortisone, pubmed-meshheading:11841998-Duodenum, pubmed-meshheading:11841998-Fetuins, pubmed-meshheading:11841998-Fluorescein-5-isothiocyanate, pubmed-meshheading:11841998-Fluorescent Dyes, pubmed-meshheading:11841998-Glycoconjugates, pubmed-meshheading:11841998-Ileum, pubmed-meshheading:11841998-Intestines, pubmed-meshheading:11841998-Jejunum, pubmed-meshheading:11841998-Lectins, pubmed-meshheading:11841998-Mice, pubmed-meshheading:11841998-N-Acetylneuraminic Acid, pubmed-meshheading:11841998-Plant Lectins, pubmed-meshheading:11841998-RNA, Messenger, pubmed-meshheading:11841998-Ribosome Inactivating Proteins, pubmed-meshheading:11841998-Sialyltransferases, pubmed-meshheading:11841998-Tissue Distribution, pubmed-meshheading:11841998-alpha-Fetoproteins
pubmed:year
2002
pubmed:articleTitle
Region-specific ontogeny of alpha-2,6-sialyltransferase during normal and cortisone-induced maturation in mouse intestine.
pubmed:affiliation
Shanghai Institute for Pediatric Research, Xinhua Hospital and Shanghai Second Medical University, Shanghai, People's Republic of China 200092.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't