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rdf:type |
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lifeskim:mentions |
umls-concept:C0017636,
umls-concept:C0025932,
umls-concept:C0086418,
umls-concept:C0206679,
umls-concept:C0596988,
umls-concept:C1425844,
umls-concept:C1442161,
umls-concept:C1552644,
umls-concept:C1822997,
umls-concept:C1823153,
umls-concept:C2349976
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pubmed:issue |
3
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pubmed:dateCreated |
2002-2-13
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pubmed:abstractText |
We previously constructed a novel recombinant herpes simplex virus with deletions in the gamma 34.5 and LAT genes. LAT was replaced by the gene for green fluorescent protein, to allow monitoring of viral transduction in vitro and in vivo. We previously confirmed that this virus, designated DM33, retains its oncolytic properties in vitro and is inhibited with respect to spontaneous reactivation. The objective of this study was to demonstrate the therapeutic efficiency of this virus in the treatment of human gliomas in nude mice.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0148-396X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
599-605; discussion 605-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11841729-Animals,
pubmed-meshheading:11841729-Antiviral Agents,
pubmed-meshheading:11841729-Brain Neoplasms,
pubmed-meshheading:11841729-Corpus Striatum,
pubmed-meshheading:11841729-Female,
pubmed-meshheading:11841729-Ganciclovir,
pubmed-meshheading:11841729-Gene Deletion,
pubmed-meshheading:11841729-Glioblastoma,
pubmed-meshheading:11841729-Green Fluorescent Proteins,
pubmed-meshheading:11841729-Herpesvirus 1, Human,
pubmed-meshheading:11841729-Humans,
pubmed-meshheading:11841729-Indicators and Reagents,
pubmed-meshheading:11841729-Injections, Intralesional,
pubmed-meshheading:11841729-Injections, Intraperitoneal,
pubmed-meshheading:11841729-Luminescent Proteins,
pubmed-meshheading:11841729-Mice,
pubmed-meshheading:11841729-Mice, Inbred BALB C,
pubmed-meshheading:11841729-Mice, Nude,
pubmed-meshheading:11841729-Mutation,
pubmed-meshheading:11841729-Neoplasm Transplantation,
pubmed-meshheading:11841729-Viral Proteins,
pubmed-meshheading:11841729-Viruses
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pubmed:year |
2002
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pubmed:articleTitle |
A herpes simplex virus type 1 mutant with gamma 34.5 and LAT deletions effectively oncolyses human U87 glioblastomas in nude mice.
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pubmed:affiliation |
Maxine Dunitz Neurosurgical Institute, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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