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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-2-12
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pubmed:abstractText |
In giant cell arteritis (GCA), inflammatory lesions typically produce interferon-gamma(IFNgamma)-- and nuclear factor kappaB (NF-kappaB)-dependent monokines. Corticosteroids influence disease activity by repressing NF-kappaB-dependent genes but have only marginal effects on IFNgamma. The current study explored whether acetylsalicylic acid (ASA) had cytokine-repressing activity in GCA and could function as a steroid-sparing agent.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
457-66
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11840449-Animals,
pubmed-meshheading:11840449-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:11840449-Aspirin,
pubmed-meshheading:11840449-Dexamethasone,
pubmed-meshheading:11840449-Drug Synergism,
pubmed-meshheading:11840449-Giant Cell Arteritis,
pubmed-meshheading:11840449-Glucocorticoids,
pubmed-meshheading:11840449-Humans,
pubmed-meshheading:11840449-Indomethacin,
pubmed-meshheading:11840449-Interferon-gamma,
pubmed-meshheading:11840449-Mice,
pubmed-meshheading:11840449-Mice, SCID,
pubmed-meshheading:11840449-Monocytes,
pubmed-meshheading:11840449-NF-kappa B,
pubmed-meshheading:11840449-Signal Transduction,
pubmed-meshheading:11840449-T-Lymphocytes,
pubmed-meshheading:11840449-Temporal Arteries,
pubmed-meshheading:11840449-Transcription, Genetic,
pubmed-meshheading:11840449-Transcription Factor AP-1
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pubmed:year |
2002
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pubmed:articleTitle |
Therapeutic effects of acetylsalicylic acid in giant cell arteritis.
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pubmed:affiliation |
Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA. weyand.cornelia@mayo.edu
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pubmed:publicationType |
Journal Article
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