|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2002-2-12
|
|
pubmed:abstractText |
We have shown that the calmodulin inhibitor W-7 suppresses torsade de pointes (TdP) without shortening the QT interval, which is consistent with other findings that QT prolongation, per se, is insufficient to generate TdP. ECGs were analyzed from a well-characterized animal model of TdP to identify more reliable predictors of this life-threatening ventricular arrhythmia.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1524-4539
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
12
|
|
pubmed:volume |
105
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
770-4
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11839636-Animals,
pubmed-meshheading:11839636-Arrhythmias, Cardiac,
pubmed-meshheading:11839636-Calmodulin,
pubmed-meshheading:11839636-Disease Models, Animal,
pubmed-meshheading:11839636-Electrocardiography,
pubmed-meshheading:11839636-Enzyme Inhibitors,
pubmed-meshheading:11839636-Heart Rate,
pubmed-meshheading:11839636-Male,
pubmed-meshheading:11839636-Methoxamine,
pubmed-meshheading:11839636-Potassium Channel Blockers,
pubmed-meshheading:11839636-Predictive Value of Tests,
pubmed-meshheading:11839636-Quaternary Ammonium Compounds,
pubmed-meshheading:11839636-Rabbits,
pubmed-meshheading:11839636-Signal Processing, Computer-Assisted,
pubmed-meshheading:11839636-Sulfonamides,
pubmed-meshheading:11839636-Torsades de Pointes
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Calmodulin inhibitor W-7 unmasks a novel electrocardiographic parameter that predicts initiation of torsade de pointes.
|
|
pubmed:affiliation |
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn 37232-6300, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
