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rdf:type |
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lifeskim:mentions |
umls-concept:C0005821,
umls-concept:C0009566,
umls-concept:C0012655,
umls-concept:C0014118,
umls-concept:C0025953,
umls-concept:C0033684,
umls-concept:C0038172,
umls-concept:C0242656,
umls-concept:C0332281,
umls-concept:C0392756,
umls-concept:C0677043,
umls-concept:C0936012,
umls-concept:C1517004,
umls-concept:C1521828,
umls-concept:C1533691
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pubmed:issue |
6
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pubmed:dateCreated |
2002-2-12
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pubmed:abstractText |
Mammalian platelets contain small, cationic, staphylocidal peptides, termed thrombin-induced platelet-microbicidal proteins (tPMPs). Evidence suggests that tPMPs play a key role in host defense against endovascular infections, such as infective endocarditis (IE). In the present study, we evaluated the influence of differences in staphylococcal tPMP-susceptibility profiles in vitro on disease severity in experimental IE.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
12
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
746-52
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11839632-Animals,
pubmed-meshheading:11839632-Anti-Bacterial Agents,
pubmed-meshheading:11839632-Aortic Valve Insufficiency,
pubmed-meshheading:11839632-Blood Proteins,
pubmed-meshheading:11839632-Disease Models, Animal,
pubmed-meshheading:11839632-Disease Progression,
pubmed-meshheading:11839632-Drug Resistance, Microbial,
pubmed-meshheading:11839632-Echocardiography,
pubmed-meshheading:11839632-Embolism,
pubmed-meshheading:11839632-Endocarditis, Bacterial,
pubmed-meshheading:11839632-Heart Valves,
pubmed-meshheading:11839632-Kidney,
pubmed-meshheading:11839632-Prognosis,
pubmed-meshheading:11839632-Rabbits,
pubmed-meshheading:11839632-Staphylococcal Infections,
pubmed-meshheading:11839632-Staphylococcus aureus,
pubmed-meshheading:11839632-Ventricular Dysfunction, Left
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pubmed:year |
2002
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pubmed:articleTitle |
In vitro susceptibility to thrombin-induced platelet microbicidal protein is associated with reduced disease progression and complication rates in experimental Staphylococcus aureus endocarditis: microbiological, histopathologic, and echocardiographic analyses.
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pubmed:affiliation |
Division of Infectious Diseases, St John's Cardiovascular Research Center and the Research & Education Institute, Torrance, Calif 90502, USA. kupferwasser@hotmail.com
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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