Source:http://linkedlifedata.com/resource/pubmed/id/11839534
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2002-2-12
|
| pubmed:abstractText |
Antenatal inflammation may be an important triggering event in the pathogenesis of bronchopulmonary dysplasia but may also accelerate fetal lung maturation. We examined the effects of intra-amniotic (IA) interleukin (IL)-1 alpha and IL-1 beta on maturation of the fetal sheep lung. These cytokine effects were compared with IA endotoxin, a potent proinflammatory stimulus that accelerated lung maturation. Date-bred ewes received 15 or 150 microg recombinant ovine IL-1 alpha or IL-1 beta or 10 mg Escherichia coli endotoxin by IA injection at 118 days gestation (term = 150 days), and fetuses were delivered at 125 days. IL-1 alpha and IL-1 beta improved lung function and increased alveolar saturated phosphatidylcholine (Sat PC) and surfactant protein mRNA expression at the higher dose. The maturation response to IL-1 alpha was greater than that to IL-1 beta, which was similar to endotoxin response. Inflammation was also more pronounced after IL-1 alpha treatment. Only endotoxin animals had residual inflammation of the fetal membranes at 7 days. Lung compliance, lung volume, and alveolar Sat PC were positively correlated with residual alveolar wash leukocyte numbers 7 days after IL-1 treatment, suggesting a link between lung inflammation and maturation.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1040-0605
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
282
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
L411-20
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11839534-Amnion,
pubmed-meshheading:11839534-Amniotic Fluid,
pubmed-meshheading:11839534-Animals,
pubmed-meshheading:11839534-Animals, Newborn,
pubmed-meshheading:11839534-Delivery, Obstetric,
pubmed-meshheading:11839534-Embryonic and Fetal Development,
pubmed-meshheading:11839534-Fetal Organ Maturity,
pubmed-meshheading:11839534-Fetus,
pubmed-meshheading:11839534-Forecasting,
pubmed-meshheading:11839534-Injections,
pubmed-meshheading:11839534-Interleukin-1,
pubmed-meshheading:11839534-Leukocyte Count,
pubmed-meshheading:11839534-Lung,
pubmed-meshheading:11839534-Pneumonia,
pubmed-meshheading:11839534-Pulmonary Surfactants,
pubmed-meshheading:11839534-RNA, Messenger,
pubmed-meshheading:11839534-Respiration,
pubmed-meshheading:11839534-Sheep
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Intra-amniotic injection of IL-1 induces inflammation and maturation in fetal sheep lung.
|
| pubmed:affiliation |
Division of Clinical Sciences, Center for Child Health Research, Perth, Australia.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|