Linked Life Data

11836610

Source:http://linkedlifedata.com/resource/pubmed/id/11836610

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pubmed-article:11836610pubmed:abstractTextSeveral investigators have demonstrated that TGF-beta stimulated clone-22 (TSC-22) regulates cell growth and differentiation, and cell death. TSC-22 is a putative transcriptional regulator containing a leucine zipper-like structure and a nuclear export signal. We previously showed the cytoplasmic localization of TSC-22 and the nuclear translocation of TSC-22 concomitant with induction of apoptosis in salivary gland cancer cells. In the present study, we attempted to identify the active domain of TSC-22 protein that regulated the biological functions of TSC-22. We constructed three mammalian expression vectors, which could produce full length TSC-22 only in cytoplasm, the leucine zipper structure of TSC-22 in both cytoplasm and nucleus, and the leucine zipper structure only in nucleus. Then, we transfected a salivary gland cancer cell line, HSG with these expression vectors, and investigated the growth profile of the transfectants. None of the TSC-22 constructs inhibited the monolayer growth and the anchorage-dependent colony formation of HSG cells. However, the leucine zipper structure of TSC-22 markedly inhibited the anchorage-independent colony formation of HSG cells (p<0.001; one way ANOVA). Full length TSC-22 also suppressed the anchorage-independent colony formation of HSG cells, although the effect of full length TSC-22 was much lower than those of the leucine zipper constructs. These observations suggest that the leucine zipper structure in TSC-22 protein is an active domain that negatively regulates the growth of salivary gland cancer cells.lld:pubmed
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pubmed-article:11836610pubmed:authorpubmed-author:YoshidaHideoHlld:pubmed
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pubmed-article:11836610pubmed:dateRevised2007-5-10lld:pubmed
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pubmed-article:11836610pubmed:articleTitleLeucine zipper structure of TSC-22 (TGF-beta stimulated clone-22) markedly inhibits the anchorage-independent growth of salivary gland cancer cells.lld:pubmed
pubmed-article:11836610pubmed:affiliationSecond Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, Tokushima 770-8504, Japan.lld:pubmed
pubmed-article:11836610pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11836610pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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