Source:http://linkedlifedata.com/resource/pubmed/id/11836268
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2002-2-11
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| pubmed:abstractText |
To date, data on pituitary adenomas in MEN type 1 (MEN1) still have to be evaluated. We analyzed the data of a large series of 324 MEN1 patients from a French and Belgian multicenter study. Data on pituitary disease were compared with those from 110 non-MEN1 patients with pituitary adenomas, matched for age, year of diagnosis, and follow-up period. Genetic analysis of the MEN1 gene was performed in 197 of the MEN1 patients. In our MEN1 series, pituitary disease occurred in 136 of 324 (42%), less frequently than hyperparathyroidism (95%, P < 0.001) and endocrine enteropancreatic tumors (54%, P < 0.01). Mean age of onset of pituitary tumors was 38.0+/-15.3 yr (range, 12-83 yr). Pituitary disease was associated with hyperparathyroidism in 90% of cases, with enteropancreatic tumors in 47%, with adrenal tumors in 16%, and with thoracic neuroendocrine tumors in 4%. Pituitary disease was the initial lesion of MEN1 in 17% of all MEN1 patients. MEN1 pituitary adenomas were significantly more frequent in women than in men (50% vs. 31%, P < 0.001). Among the 136 pituitary adenomas, there were 85 prolactinomas and 12 GH-secreting, 6 ACTH-secreting, 13 cosecreting, and 20 nonsecreting tumors. Eighty-five percent of MEN1-related pituitary lesions were macroadenomas (vs. 42% in non-MEN1 patients, P < 0.001), including 32% of invasive cases. Among secreting adenomas, hormonal hypersecretion was normalized, after treatment, in only 42% (vs. 90% in non-MEN1 patients, P < 0.001), with a median follow-up of 11.4 yr. No correlation was found between the type of MEN1 germ-line mutation and the presence or absence of pituitary adenoma. Our study, based on a large group of MEN1 patients, shows that pituitary adenomas occur in 42% of the cases and are characterized by a larger size and a more aggressive presentation than without MEN1.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0021-972X
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| pubmed:author |
pubmed-author:BeckersAlbertA,
pubmed-author:BoureilleFrançoiseF,
pubmed-author:CalenderAlainA,
pubmed-author:ChambeBéatriceB,
pubmed-author:CougardPatrickP,
pubmed-author:GoudetPierreP,
pubmed-author:MontvernayCorinneC,
pubmed-author:MuratArnaudA,
pubmed-author:SassolasGenevièveG,
pubmed-author:VergèsBrunoB
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| pubmed:issnType |
Print
|
| pubmed:volume |
87
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
457-65
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11836268-Adenoma,
pubmed-meshheading:11836268-Adult,
pubmed-meshheading:11836268-Age Distribution,
pubmed-meshheading:11836268-Disease Susceptibility,
pubmed-meshheading:11836268-Female,
pubmed-meshheading:11836268-Gene Deletion,
pubmed-meshheading:11836268-Genetic Predisposition to Disease,
pubmed-meshheading:11836268-Germ-Line Mutation,
pubmed-meshheading:11836268-Hormones,
pubmed-meshheading:11836268-Humans,
pubmed-meshheading:11836268-Incidence,
pubmed-meshheading:11836268-Male,
pubmed-meshheading:11836268-Middle Aged,
pubmed-meshheading:11836268-Multiple Endocrine Neoplasia Type 1,
pubmed-meshheading:11836268-Pituitary Neoplasms,
pubmed-meshheading:11836268-Severity of Illness Index,
pubmed-meshheading:11836268-Sex Distribution,
pubmed-meshheading:11836268-Treatment Outcome
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| pubmed:year |
2002
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| pubmed:articleTitle |
Pituitary disease in MEN type 1 (MEN1): data from the France-Belgium MEN1 multicenter study.
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| pubmed:affiliation |
Department of Endocrinology, University Hospital, 21000 Dijon, France. bruno.verges@chu-dijon.fr
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Multicenter Study
|