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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-2-8
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pubmed:abstractText |
Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase blocks the mevalonate metabolic pathway, which is necessary for the isoprenylation of a number of small guanosine triphosphatases. We examined the effects of HMG-CoA reductase inhibitors, fluvastatin and lovastatin, on human pancreatic cancer cell invasion in vitro and experimental liver metastasis in vivo.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
308-17
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11832446-Adenocarcinoma,
pubmed-meshheading:11832446-Animals,
pubmed-meshheading:11832446-Cell Division,
pubmed-meshheading:11832446-Cell Membrane,
pubmed-meshheading:11832446-Cytosol,
pubmed-meshheading:11832446-Epidermal Growth Factor,
pubmed-meshheading:11832446-Fatty Acids, Monounsaturated,
pubmed-meshheading:11832446-Humans,
pubmed-meshheading:11832446-Hydroxymethylglutaryl CoA Reductases,
pubmed-meshheading:11832446-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:11832446-Hypercholesterolemia,
pubmed-meshheading:11832446-Indoles,
pubmed-meshheading:11832446-Liver Neoplasms, Experimental,
pubmed-meshheading:11832446-Lovastatin,
pubmed-meshheading:11832446-Mice,
pubmed-meshheading:11832446-Mice, Nude,
pubmed-meshheading:11832446-Neoplasm Invasiveness,
pubmed-meshheading:11832446-Pancreatic Neoplasms,
pubmed-meshheading:11832446-Tumor Cells, Cultured,
pubmed-meshheading:11832446-rhoA GTP-Binding Protein
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pubmed:year |
2002
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pubmed:articleTitle |
3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis.
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pubmed:affiliation |
Department of Tumor Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan. kusama-to@mail.mc.pref.osaka.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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