Linked Life Data

11831703

Source:http://linkedlifedata.com/resource/pubmed/id/11831703

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-2-7
pubmed:abstractText
The two 5'-proximal open reading frames of peanut clump virus RNA 2, which encode the coat protein of 23 kDa and a protein of 39 kDa (P39), are both translated in vitro from genomic RNA 2. We have studied the translational strategy involved in the initiation at the second AUG of RNA 2, which is the initiation codon of P39. Mutation experiments with synthetic transcripts corresponding to the 5'-half of RNA 2 ruled out mechanisms of P39 translation initiation involving termination-reinitiation and internal ribosomes entry. The results were consistent, however, with a leaky scanning mechanism for P39 initiation, in which about one-third of the ribosomes fail to initiate translation of coat protein and scan along the template to initiate translation at the AUG of the P39 gene, more than 1000 residues in from the 5'-terminus of the RNA 2.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0042-6822
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
208
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
215-25
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Translation of the second gene of peanut clump virus RNA 2 occurs by leaky scanning in vitro.
pubmed:affiliation
Institut de Biologie Moléculaire des Plantes, CNRS, Université Louis Pasteur, Strasbourg, France.
pubmed:publicationType
Journal Article