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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2002-2-6
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pubmed:abstractText |
Orexin A, synthesised in the posterolateral hypothalamus, has widespread distribution including the paraventricular nucleus (PVN), which is rich in thyrotropin-releasing hormone (TRH) neurones. Nerve fibres in the PVN synapse on neurones that send polysynaptic projections to brown adipose tissue (BAT), which is important in thermogenesis. A number of observations suggests orexin A may be involved in regulation of metabolism and thermogenesis. We investigated the effect of orexin A injected intracerebroventricularly (ICV) on thyroid-stimulating hormone (TSH) and thyroid hormones in male rats. We then examined the effect of chronic iPVN injections of orexin A on plasma TSH and uncoupling protein-1 (UCP-1) protein in BAT. Orexin A (3 nmol) administered ICV significantly suppressed plasma TSH at 10 and 90 min. Orexin A (0.3 nmol) administered into the PVN twice daily for 3 days significantly increased day-time 2-h food intake, but did not significantly alter nocturnal food intake. Though chronic iPVN orexin A altered diurnal food intake, there was no effect on 24-h food intake or body weight. Furthermore, orexin A administered chronically into the PVN did not alter UCP-1 level in BAT, or plasma hormones relative to saline injected animals. Chronic iPVN orexin A does not appear to influence thermogenesis through activation of UCP-1 or the thyroid axis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Pituitary Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Thyrotropin,
http://linkedlifedata.com/resource/pubmed/chemical/Thyroxine,
http://linkedlifedata.com/resource/pubmed/chemical/Triiodothyronine,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial uncoupling protein,
http://linkedlifedata.com/resource/pubmed/chemical/orexins
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0167-0115
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
61-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11830278-Adipose Tissue, Brown,
pubmed-meshheading:11830278-Animals,
pubmed-meshheading:11830278-Body Weight,
pubmed-meshheading:11830278-Carrier Proteins,
pubmed-meshheading:11830278-Eating,
pubmed-meshheading:11830278-Injections, Intraventricular,
pubmed-meshheading:11830278-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:11830278-Ion Channels,
pubmed-meshheading:11830278-Male,
pubmed-meshheading:11830278-Membrane Proteins,
pubmed-meshheading:11830278-Mitochondrial Proteins,
pubmed-meshheading:11830278-Neuropeptides,
pubmed-meshheading:11830278-Pituitary Hormones,
pubmed-meshheading:11830278-Rats,
pubmed-meshheading:11830278-Rats, Wistar,
pubmed-meshheading:11830278-Thyroid Gland,
pubmed-meshheading:11830278-Thyrotropin,
pubmed-meshheading:11830278-Thyroxine,
pubmed-meshheading:11830278-Triiodothyronine
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pubmed:year |
2002
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pubmed:articleTitle |
Chronic intraparaventricular nuclear administration of orexin A in male rats does not alter thyroid axis or uncoupling protein-1 in brown adipose tissue.
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pubmed:affiliation |
ICSM Endocrine Unit, Hammersmith Hospital, Du Cane Road, W12 ONN, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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