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rdf:type |
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lifeskim:mentions |
umls-concept:C0007131,
umls-concept:C0010749,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0030685,
umls-concept:C0391871,
umls-concept:C0521447,
umls-concept:C0680255,
umls-concept:C1159825,
umls-concept:C1283071,
umls-concept:C1521761,
umls-concept:C1963578
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pubmed:issue |
2
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pubmed:dateCreated |
2002-2-5
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pubmed:abstractText |
Although we have previously shown that inhibition of nuclear factor kappaB sensitizes non-small cell lung cancer cells to chemotherapy-mediated cell death, the apoptotic pathways mediating this process are unknown. The purpose of this study was to determine whether chemosensitivity after the inhibition of nuclear factor kappaB in non-small cell lung cancer cells is a mitochondrial and caspase-mediated process and whether it is dependent on nuclear factor kappaB transcriptional activity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-5223
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
310-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11828291-Antimetabolites, Antineoplastic,
pubmed-meshheading:11828291-Apoptosis,
pubmed-meshheading:11828291-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:11828291-Caspases,
pubmed-meshheading:11828291-Cytochrome c Group,
pubmed-meshheading:11828291-DNA Fragmentation,
pubmed-meshheading:11828291-Deoxycytidine,
pubmed-meshheading:11828291-Enzyme Activation,
pubmed-meshheading:11828291-Humans,
pubmed-meshheading:11828291-Lung Neoplasms,
pubmed-meshheading:11828291-NF-kappa B,
pubmed-meshheading:11828291-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Inhibition of nuclear factor kappaB chemosensitizes non-small cell lung cancer through cytochrome c release and caspase activation.
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pubmed:affiliation |
Department of Surgery, The University of Virginia, Charlottesville, VA 22908-0679, USA. djones@virginia.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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