|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2002-2-5
|
|
pubmed:abstractText |
Ischemia and oxidative stress are the leading mechanisms for tissue injury. An ideal strategy for preventive/protective therapy would be to develop an approach that could confer long-term transgene expression and, consequently, tissue protection from repeated ischemia/reperfusion injury with a single administration of a therapeutic gene. In the present study, we used recombinant adeno-associated virus (rAAV) as a vector for direct delivery of the cytoprotective gene heme oxygenase-1 (HO-1) into the rat myocardium, with the purpose of evaluating this strategy as a therapeutic approach for long-term protection from ischemia-induced myocardial injury.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1524-4539
|
|
pubmed:author |
pubmed-author:AgrawalReituR,
pubmed-author:Dell'AcquaGiorgioG,
pubmed-author:DzauVictor JVJ,
pubmed-author:EhsanAfshinA,
pubmed-author:GrieseDaniel PDP,
pubmed-author:LayneMatthew DMD,
pubmed-author:MangiAbeel AAA,
pubmed-author:MannMichael JMJ,
pubmed-author:MeloLuis GLG,
pubmed-author:OyamaJunichiJ,
pubmed-author:PerrellaMark AMA,
pubmed-author:RezvaniMojganM,
pubmed-author:YetShaw-FangSF,
pubmed-author:ZhangLunanL
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
5
|
|
pubmed:volume |
105
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
602-7
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:11827926-Animals,
pubmed-meshheading:11827926-Apoptosis,
pubmed-meshheading:11827926-Coronary Vessels,
pubmed-meshheading:11827926-Cytokines,
pubmed-meshheading:11827926-Cytoprotection,
pubmed-meshheading:11827926-Dependovirus,
pubmed-meshheading:11827926-Disease Models, Animal,
pubmed-meshheading:11827926-Gene Expression,
pubmed-meshheading:11827926-Gene Therapy,
pubmed-meshheading:11827926-Genetic Vectors,
pubmed-meshheading:11827926-Heme Oxygenase (Decyclizing),
pubmed-meshheading:11827926-Heme Oxygenase-1,
pubmed-meshheading:11827926-Humans,
pubmed-meshheading:11827926-Ligation,
pubmed-meshheading:11827926-Male,
pubmed-meshheading:11827926-Membrane Proteins,
pubmed-meshheading:11827926-Myocardial Infarction,
pubmed-meshheading:11827926-Myocardium,
pubmed-meshheading:11827926-Oxidative Stress,
pubmed-meshheading:11827926-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:11827926-Rats,
pubmed-meshheading:11827926-Rats, Sprague-Dawley,
pubmed-meshheading:11827926-Time,
pubmed-meshheading:11827926-Transgenes
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene.
|
|
pubmed:affiliation |
Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
