|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0011209,
umls-concept:C0020507,
umls-concept:C0020887,
umls-concept:C0026046,
umls-concept:C0026336,
umls-concept:C0034493,
umls-concept:C0205276,
umls-concept:C0205314,
umls-concept:C0246415,
umls-concept:C0392756,
umls-concept:C0450442,
umls-concept:C0679622
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|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2002-2-5
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|
pubmed:abstractText |
Docetaxel (DOC) is a novel microtubule polymerizing agent, with superior antiproliferative properties as compared to paclitaxel. DOC is therefore a potential therapeutic tool for the prevention of restenosis following angioplasty. However, DOC has systemic toxicity such as leukocytopenia, which occurs in a dose-dependent manner. To minimize such adverse effects, we carried out local delivery of low-dose DOC directly to injured vessel sites.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0008-6363
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
1
|
|
pubmed:volume |
53
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
481-6
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|
pubmed:dateRevised |
2010-11-18
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|
pubmed:meshHeading |
pubmed-meshheading:11827699-Administration, Topical,
pubmed-meshheading:11827699-Analysis of Variance,
pubmed-meshheading:11827699-Animals,
pubmed-meshheading:11827699-Antineoplastic Agents,
pubmed-meshheading:11827699-Balloon Dilation,
pubmed-meshheading:11827699-Drug Delivery Systems,
pubmed-meshheading:11827699-Hyperplasia,
pubmed-meshheading:11827699-Iliac Artery,
pubmed-meshheading:11827699-Image Processing, Computer-Assisted,
pubmed-meshheading:11827699-Leukocyte Count,
pubmed-meshheading:11827699-Paclitaxel,
pubmed-meshheading:11827699-Rabbits,
pubmed-meshheading:11827699-Taxoids,
pubmed-meshheading:11827699-Tunica Intima
|
|
pubmed:year |
2002
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|
pubmed:articleTitle |
Local delivery of low-dose docetaxel, a novel microtubule polymerizing agent, reduces neointimal hyperplasia in a balloon-injured rabbit iliac artery model.
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|
pubmed:affiliation |
National Cardiovascular Center, Division of Cardiology, Department of Medicine, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan. syasuda@hsp.ncvc.go.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
